Transcription Blockage Leads to New Beginnings
Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the remova...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-07-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-273X/5/3/1600 |
| _version_ | 1818435484218556416 |
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| author | Leonardo C. Andrade-Lima Artur Veloso Mats Ljungman |
| author_facet | Leonardo C. Andrade-Lima Artur Veloso Mats Ljungman |
| author_sort | Leonardo C. Andrade-Lima |
| collection | DOAJ |
| description | Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes. |
| first_indexed | 2024-12-14T16:53:37Z |
| format | Article |
| id | doaj.art-d1ddb81ce0b641ee89dd9e337e0de21f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-14T16:53:37Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d1ddb81ce0b641ee89dd9e337e0de21f2022-12-21T22:54:00ZengMDPI AGBiomolecules2218-273X2015-07-01531600161710.3390/biom5031600biom5031600Transcription Blockage Leads to New BeginningsLeonardo C. Andrade-Lima0Artur Veloso1Mats Ljungman2Department of Radiation Oncology and Translational Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USADepartment of Radiation Oncology and Translational Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USADepartment of Radiation Oncology and Translational Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USAEnvironmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes.http://www.mdpi.com/2218-273X/5/3/1600DNA damageDNA repairRNA polymerase IIrecovery of RNA synthesis |
| spellingShingle | Leonardo C. Andrade-Lima Artur Veloso Mats Ljungman Transcription Blockage Leads to New Beginnings Biomolecules DNA damage DNA repair RNA polymerase II recovery of RNA synthesis |
| title | Transcription Blockage Leads to New Beginnings |
| title_full | Transcription Blockage Leads to New Beginnings |
| title_fullStr | Transcription Blockage Leads to New Beginnings |
| title_full_unstemmed | Transcription Blockage Leads to New Beginnings |
| title_short | Transcription Blockage Leads to New Beginnings |
| title_sort | transcription blockage leads to new beginnings |
| topic | DNA damage DNA repair RNA polymerase II recovery of RNA synthesis |
| url | http://www.mdpi.com/2218-273X/5/3/1600 |
| work_keys_str_mv | AT leonardocandradelima transcriptionblockageleadstonewbeginnings AT arturveloso transcriptionblockageleadstonewbeginnings AT matsljungman transcriptionblockageleadstonewbeginnings |