CD16 CAR-T cells enhance antitumor activity of CpG ODN-loaded nanoparticle-adjuvanted tumor antigen-derived vaccinevia ADCC approach

CD16 CAR-T cells enhance antitumor activity of CpG ODN-loaded nanoparticle-adjuvanted tumor antigen-derived vaccinevia ADCC approach

Abstract Background Combinatorial immunotherapy strategies for enhancing the responsiveness of immune system have shown great promise for cancer therapy. Engineered nanoformulation incorporated toll-like receptor (TLR) 9 agonist CpG ODN has shown more positive results in suppressing tumor growth and...

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Bibliographic Details
Main Authors: Xiaofei Zhang, Qin Hu, Xuesong He, Xinyue Cui, Zhaoyuan Liang, Li Wang, Xiongwei Deng, Ze Zhang, Wang Sheng, Xiaodong D. Han
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Nanobiotechnology
Subjects:
Vaccine
CpG ODN
Neoantigen
CD16
Immunotherapy
Online Access:https://doi.org/10.1186/s12951-023-01900-8

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