Sex and Response to Cardioprotective Conditioning Maneuvers
Ischemic heart disease (IHD) is a multifactorial pathological condition strictly related to genetic, dietary, and lifestyle factors. Its morbidity and mortality rate represent one of the most important pathological issues that today involve younger people in a stronger way than in the past. IHD clin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.667961/full |
| _version_ | 1818640270327021568 |
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| author | Giulia Querio Federica Geddo Susanna Antoniotti Maria Pia Gallo Claudia Penna |
| author_facet | Giulia Querio Federica Geddo Susanna Antoniotti Maria Pia Gallo Claudia Penna |
| author_sort | Giulia Querio |
| collection | DOAJ |
| description | Ischemic heart disease (IHD) is a multifactorial pathological condition strictly related to genetic, dietary, and lifestyle factors. Its morbidity and mortality rate represent one of the most important pathological issues that today involve younger people in a stronger way than in the past. IHD clinical outcomes are difficult to treat and have a high economic impact on health care. So prevention of this pathological condition through cardioprotective maneuvers represents the first line of intervention, as already underlined by several animal and human studies. Even if the time of intervention is important to prevent severe outcomes, many studies highlight that sex-dependent responses are crucial for the result of cardioprotective procedures. In this scenario sexual hormones have revealed an important role in cardioprotective approach, as women seem to be more protected toward cardiac insults when compared to male counterparts. The aim of this mini review is to show the molecular pathways involved in cardioprotective protocols and to elucidate how sexual hormones can contribute in ameliorating or worsening the physiological responses to IHD. |
| first_indexed | 2024-12-16T23:08:36Z |
| format | Article |
| id | doaj.art-d1dea207c2fb4263b5ded34b4c515d5b |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-16T23:08:36Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-d1dea207c2fb4263b5ded34b4c515d5b2022-12-21T22:12:29ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-05-011210.3389/fphys.2021.667961667961Sex and Response to Cardioprotective Conditioning ManeuversGiulia Querio0Federica Geddo1Susanna Antoniotti2Maria Pia Gallo3Claudia Penna4Department of Life Sciences and Systems Biology, University of Turin, Turin, ItalyDepartment of Life Sciences and Systems Biology, University of Turin, Turin, ItalyDepartment of Life Sciences and Systems Biology, University of Turin, Turin, ItalyDepartment of Life Sciences and Systems Biology, University of Turin, Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyIschemic heart disease (IHD) is a multifactorial pathological condition strictly related to genetic, dietary, and lifestyle factors. Its morbidity and mortality rate represent one of the most important pathological issues that today involve younger people in a stronger way than in the past. IHD clinical outcomes are difficult to treat and have a high economic impact on health care. So prevention of this pathological condition through cardioprotective maneuvers represents the first line of intervention, as already underlined by several animal and human studies. Even if the time of intervention is important to prevent severe outcomes, many studies highlight that sex-dependent responses are crucial for the result of cardioprotective procedures. In this scenario sexual hormones have revealed an important role in cardioprotective approach, as women seem to be more protected toward cardiac insults when compared to male counterparts. The aim of this mini review is to show the molecular pathways involved in cardioprotective protocols and to elucidate how sexual hormones can contribute in ameliorating or worsening the physiological responses to IHD.https://www.frontiersin.org/articles/10.3389/fphys.2021.667961/fullcardioprotectionischemic heart diseaseestrogensexconditioninggender |
| spellingShingle | Giulia Querio Federica Geddo Susanna Antoniotti Maria Pia Gallo Claudia Penna Sex and Response to Cardioprotective Conditioning Maneuvers Frontiers in Physiology cardioprotection ischemic heart disease estrogen sex conditioning gender |
| title | Sex and Response to Cardioprotective Conditioning Maneuvers |
| title_full | Sex and Response to Cardioprotective Conditioning Maneuvers |
| title_fullStr | Sex and Response to Cardioprotective Conditioning Maneuvers |
| title_full_unstemmed | Sex and Response to Cardioprotective Conditioning Maneuvers |
| title_short | Sex and Response to Cardioprotective Conditioning Maneuvers |
| title_sort | sex and response to cardioprotective conditioning maneuvers |
| topic | cardioprotection ischemic heart disease estrogen sex conditioning gender |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.667961/full |
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