Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux through ATP-citrate lyase (ACLY) to reduce cy...

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Bibliographic Details
Main Author:	Patrick C. Bradshaw
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Antioxidants
Subjects:	acetyl-CoA aging autophagy acetylation histone deacetylase calorie restriction
Online Access:	https://www.mdpi.com/2076-3921/10/4/572

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