Non-C<sub>2</sub>-Symmetric <i>Bis</i>-Benzimidazolium Salt Applied in the Synthesis of Sterically Hindered Biaryls
A novel non-C<sub>2</sub>-symmetric <i>bis</i>-benzimidazolium salt derived from (±)-valinol has been prepared by a simple and straightforward process in good yield. The structure of <i>bis</i>-benzimidazolium salt provided a bulky steric group on the ethylene bri...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/21/6703 |
| Summary: | A novel non-C<sub>2</sub>-symmetric <i>bis</i>-benzimidazolium salt derived from (±)-valinol has been prepared by a simple and straightforward process in good yield. The structure of <i>bis</i>-benzimidazolium salt provided a bulky steric group on the ethylene bridge; which facilitates the catalytic efficacy in the C(<i>sp</i><sup>2</sup>)–C(<i>sp</i><sup>2</sup>) formation. Its catalytic activity in Suzuki–Miyaura cross-coupling reaction of unactivated aryl chlorides has been found to have high efficacy in 1 mol% Pd loading. This protocol demonstrated the potential on the synthesis of sterically hindered biaryls. |
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| ISSN: | 1420-3049 |