A Review of Natural Products for Prevention of Acute Kidney Injury
Background and Objectives: acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products—measured by blood urea nitrogen (BUN) and serum creatinine lev...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/11/1266 |
| _version_ | 1827676187345813504 |
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| author | Hyun Goo Kang Hyun Ki Lee Kyu Bong Cho Sang Il Park |
| author_facet | Hyun Goo Kang Hyun Ki Lee Kyu Bong Cho Sang Il Park |
| author_sort | Hyun Goo Kang |
| collection | DOAJ |
| description | Background and Objectives: acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products—measured by blood urea nitrogen (BUN) and serum creatinine levels—over the course of hours to weeks. AKI occurs in about 20% of all hospitalized patients and is more common in the elderly. Therefore, it is necessary to prevent the occurrence of AKI, and to detect and treat early, since it is known that a prolonged period of kidney injury increases cardiovascular complications and the risk of death. Despite advances in modern medicine, there are no consistent treatment strategies for preventing the progression to chronic kidney disease. Through many studies, the safety and efficacy of natural products have been proven, and based on this, the time and cost required for new drug development can be reduced. In addition, research results on natural products are highly anticipated in the prevention and treatment of various diseases. In relation to AKI, many papers have reported that many natural products can prevent and treat AKI. Conclusions: in this paper, the results of studies on natural products related to AKI were found and summarized, and the mechanism by which the efficacy of AKI was demonstrated was reviewed. Many natural products show that AKI can be prevented and treated, suggesting that these natural products can help to develop new drugs. In addition, we may be helpful to elucidate additional mechanisms and meta-analysis in future natural product studies. |
| first_indexed | 2024-03-10T05:18:13Z |
| format | Article |
| id | doaj.art-d1e1ea71adc54d378217176d596014f2 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T05:18:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-d1e1ea71adc54d378217176d596014f22023-11-23T00:18:15ZengMDPI AGMedicina1010-660X1648-91442021-11-015711126610.3390/medicina57111266A Review of Natural Products for Prevention of Acute Kidney InjuryHyun Goo Kang0Hyun Ki Lee1Kyu Bong Cho2Sang Il Park3Department of Optometry, Catholic Kwandong University, Gangneung 20561, KoreaSchool of Game, DongYang University, Dongducheon 11307, KoreaDepartment of Biomedical Laboratory Science, Shinhan University, Uijeonbu 11644, KoreaDepartment of Optometry, Catholic Kwandong University, Gangneung 20561, KoreaBackground and Objectives: acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products—measured by blood urea nitrogen (BUN) and serum creatinine levels—over the course of hours to weeks. AKI occurs in about 20% of all hospitalized patients and is more common in the elderly. Therefore, it is necessary to prevent the occurrence of AKI, and to detect and treat early, since it is known that a prolonged period of kidney injury increases cardiovascular complications and the risk of death. Despite advances in modern medicine, there are no consistent treatment strategies for preventing the progression to chronic kidney disease. Through many studies, the safety and efficacy of natural products have been proven, and based on this, the time and cost required for new drug development can be reduced. In addition, research results on natural products are highly anticipated in the prevention and treatment of various diseases. In relation to AKI, many papers have reported that many natural products can prevent and treat AKI. Conclusions: in this paper, the results of studies on natural products related to AKI were found and summarized, and the mechanism by which the efficacy of AKI was demonstrated was reviewed. Many natural products show that AKI can be prevented and treated, suggesting that these natural products can help to develop new drugs. In addition, we may be helpful to elucidate additional mechanisms and meta-analysis in future natural product studies.https://www.mdpi.com/1648-9144/57/11/1266acute kidney injurypreventionnatural productsantioxidant |
| spellingShingle | Hyun Goo Kang Hyun Ki Lee Kyu Bong Cho Sang Il Park A Review of Natural Products for Prevention of Acute Kidney Injury Medicina acute kidney injury prevention natural products antioxidant |
| title | A Review of Natural Products for Prevention of Acute Kidney Injury |
| title_full | A Review of Natural Products for Prevention of Acute Kidney Injury |
| title_fullStr | A Review of Natural Products for Prevention of Acute Kidney Injury |
| title_full_unstemmed | A Review of Natural Products for Prevention of Acute Kidney Injury |
| title_short | A Review of Natural Products for Prevention of Acute Kidney Injury |
| title_sort | review of natural products for prevention of acute kidney injury |
| topic | acute kidney injury prevention natural products antioxidant |
| url | https://www.mdpi.com/1648-9144/57/11/1266 |
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