Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms
The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief rev...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-08-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/3/3/498 |
| _version_ | 1797762080896450560 |
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| author | Sasha E. Parets Carrie E. Bedient Ramkumar Menon Alicia K. Smith |
| author_facet | Sasha E. Parets Carrie E. Bedient Ramkumar Menon Alicia K. Smith |
| author_sort | Sasha E. Parets |
| collection | DOAJ |
| description | The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB. |
| first_indexed | 2024-03-12T19:22:13Z |
| format | Article |
| id | doaj.art-d1e2440bf3174e6296dd49442aa9b499 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T19:22:13Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-d1e2440bf3174e6296dd49442aa9b4992023-08-02T05:05:06ZengMDPI AGBiology2079-77372014-08-013349851310.3390/biology3030498biology3030498Preterm Birth and Its Long-Term Effects: Methylation to MechanismsSasha E. Parets0Carrie E. Bedient1Ramkumar Menon2Alicia K. Smith3Genetics and Molecular Biology Program, Emory University, Atlanta, GA 30322, USADepartment of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USADivision of Maternal-Fetal Medicine Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USAGenetics and Molecular Biology Program, Emory University, Atlanta, GA 30322, USAThe epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.http://www.mdpi.com/2079-7737/3/3/498DNA methylationpreterm birthpregnancyDOHaDepigeneticdevelopmental programminggestational age |
| spellingShingle | Sasha E. Parets Carrie E. Bedient Ramkumar Menon Alicia K. Smith Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms Biology DNA methylation preterm birth pregnancy DOHaD epigenetic developmental programming gestational age |
| title | Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms |
| title_full | Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms |
| title_fullStr | Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms |
| title_full_unstemmed | Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms |
| title_short | Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms |
| title_sort | preterm birth and its long term effects methylation to mechanisms |
| topic | DNA methylation preterm birth pregnancy DOHaD epigenetic developmental programming gestational age |
| url | http://www.mdpi.com/2079-7737/3/3/498 |
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