Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk
Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavi...
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MDPI AG
2020-09-01
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| Online Access: | https://www.mdpi.com/1996-1944/13/19/4328 |
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| author | Martyna Pajewska-Szmyt Ewelina Biniewska Bogusław Buszewski Renata Gadzała-Kopciuch |
| author_facet | Martyna Pajewska-Szmyt Ewelina Biniewska Bogusław Buszewski Renata Gadzała-Kopciuch |
| author_sort | Martyna Pajewska-Szmyt |
| collection | DOAJ |
| description | Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r<sup>2</sup> from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL<sup>−1</sup>; LOQ from 3.6–8.1 ng mL<sup>−1</sup>), which makes their quantitative analysis in real samples feasible. |
| first_indexed | 2024-03-10T15:59:13Z |
| format | Article |
| id | doaj.art-d1e33454cad14e48a4ae313bf7ed3ed6 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T15:59:13Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-d1e33454cad14e48a4ae313bf7ed3ed62023-11-20T15:27:54ZengMDPI AGMaterials1996-19442020-09-011319432810.3390/ma13194328Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast MilkMartyna Pajewska-Szmyt0Ewelina Biniewska1Bogusław Buszewski2Renata Gadzała-Kopciuch3Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87100 Toruń, PolandDepartment of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87100 Toruń, PolandDepartment of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87100 Toruń, PolandDepartment of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87100 Toruń, PolandMagnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r<sup>2</sup> from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL<sup>−1</sup>; LOQ from 3.6–8.1 ng mL<sup>−1</sup>), which makes their quantitative analysis in real samples feasible.https://www.mdpi.com/1996-1944/13/19/4328magnetic sorbentsmolecularly imprinted polymersparabensbreast milksample preparationseparation field |
| spellingShingle | Martyna Pajewska-Szmyt Ewelina Biniewska Bogusław Buszewski Renata Gadzała-Kopciuch Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk Materials magnetic sorbents molecularly imprinted polymers parabens breast milk sample preparation separation field |
| title | Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk |
| title_full | Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk |
| title_fullStr | Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk |
| title_full_unstemmed | Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk |
| title_short | Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk |
| title_sort | synthesis of magnetic molecularly imprinted polymer sorbents for isolation of parabens from breast milk |
| topic | magnetic sorbents molecularly imprinted polymers parabens breast milk sample preparation separation field |
| url | https://www.mdpi.com/1996-1944/13/19/4328 |
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