Neopterin in Bone Banking
Not only in blood transfusion, but also in transplantation of allogenous bone, infection of patients with bacteria and especially with virus is possible. Neopterin as an unspecific marker of an activated cellmediated immune response is elevated in fresh viral infection even before antibodies are det...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
1998-11-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.1998.9.4.192 |
| _version_ | 1818729586386534400 |
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| author | Peters K. M. Klosterhalfen B. |
| author_facet | Peters K. M. Klosterhalfen B. |
| author_sort | Peters K. M. |
| collection | DOAJ |
| description | Not only in blood transfusion, but also in transplantation of allogenous bone, infection of patients with bacteria and especially with virus is possible. Neopterin as an unspecific marker of an activated cellmediated immune response is elevated in fresh viral infection even before antibodies are detectable. Additional determination of neopterin in bone banking can further reduce the already little risk of a still antibody-negative HIV infection in a spongiosa donor. If a first HIV-antibody test is negative and serum neopterin lies within normal range, a second HIV-test six months after operation, which is otherwise obligatory in bone banking today, can be cancelled and the allograft can be given free for transplantation assuming negative results obtained by other screening criteria. |
| first_indexed | 2024-12-17T22:48:15Z |
| format | Article |
| id | doaj.art-d1e368e41b40443ba74157e80b31045b |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-17T22:48:15Z |
| publishDate | 1998-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-d1e368e41b40443ba74157e80b31045b2022-12-21T21:29:45ZengDe GruyterPteridines0933-48072195-47201998-11-019419219510.1515/pteridines.1998.9.4.192Neopterin in Bone BankingPeters K. M.0Klosterhalfen B.1Orthopaedic Clinic, Rhein-Sieg-Klinik NuembrechtInstitute of Pathology, RWTH AachenNot only in blood transfusion, but also in transplantation of allogenous bone, infection of patients with bacteria and especially with virus is possible. Neopterin as an unspecific marker of an activated cellmediated immune response is elevated in fresh viral infection even before antibodies are detectable. Additional determination of neopterin in bone banking can further reduce the already little risk of a still antibody-negative HIV infection in a spongiosa donor. If a first HIV-antibody test is negative and serum neopterin lies within normal range, a second HIV-test six months after operation, which is otherwise obligatory in bone banking today, can be cancelled and the allograft can be given free for transplantation assuming negative results obtained by other screening criteria.https://doi.org/10.1515/pteridines.1998.9.4.192neopterinbone bankinghiv infection |
| spellingShingle | Peters K. M. Klosterhalfen B. Neopterin in Bone Banking Pteridines neopterin bone banking hiv infection |
| title | Neopterin in Bone Banking |
| title_full | Neopterin in Bone Banking |
| title_fullStr | Neopterin in Bone Banking |
| title_full_unstemmed | Neopterin in Bone Banking |
| title_short | Neopterin in Bone Banking |
| title_sort | neopterin in bone banking |
| topic | neopterin bone banking hiv infection |
| url | https://doi.org/10.1515/pteridines.1998.9.4.192 |
| work_keys_str_mv | AT peterskm neopterininbonebanking AT klosterhalfenb neopterininbonebanking |