Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide
We review the apparent discrepancies between studies that report anti-inflammatory effects of cerium oxide nanoparticles (CeO2 NPs) through their reactive oxygen species-chelating properties and immunological studies highlighting their toxicity. We observe that several underappreciated parameters, s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00970/full |
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| author | Eudald Casals Muriel F. Gusta Jordi Piella Gregori Casals Wladimiro Jiménez Wladimiro Jiménez Victor Puntes Victor Puntes Victor Puntes |
| author_facet | Eudald Casals Muriel F. Gusta Jordi Piella Gregori Casals Wladimiro Jiménez Wladimiro Jiménez Victor Puntes Victor Puntes Victor Puntes |
| author_sort | Eudald Casals |
| collection | DOAJ |
| description | We review the apparent discrepancies between studies that report anti-inflammatory effects of cerium oxide nanoparticles (CeO2 NPs) through their reactive oxygen species-chelating properties and immunological studies highlighting their toxicity. We observe that several underappreciated parameters, such as aggregation size and degree of impurity, are critical determinants that need to be carefully addressed to better understand the NP biological effects in order to unleash their potential clinical benefits. This is because NPs can evolve toward different states, depending on the environment where they have been dispersed and how they have been dispersed. As a consequence, final characteristics of NPs can be very different from what was initially designed and produced in the laboratory. Thus, aggregation, corrosion, and interaction with extracellular matrix proteins critically modify NP features and fate. These modifications depend to a large extent on the characteristics of the biological media in which the NPs are dispersed. As a consequence, when reviewing the scientific literature, it seems that the aggregation state of NPs, which depends on the characteristics of the dispersing media, may be more significant than the composition or original size of the NPs. In this work, we focus on CeO2 NPs, which are reported sometimes to be protective and anti-inflammatory, and sometimes toxic and pro-inflammatory. |
| first_indexed | 2024-12-12T08:28:55Z |
| format | Article |
| id | doaj.art-d1e3d17774d742f8830f57c6af7bd405 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T08:28:55Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d1e3d17774d742f8830f57c6af7bd4052022-12-22T00:31:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-08-01810.3389/fimmu.2017.00970264030Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium OxideEudald Casals0Muriel F. Gusta1Jordi Piella2Gregori Casals3Wladimiro Jiménez4Wladimiro Jiménez5Victor Puntes6Victor Puntes7Victor Puntes8Vall d’Hebron Institut of Research (VHIR), Barcelona, SpainVall d’Hebron Institut of Research (VHIR), Barcelona, SpainInstitut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, Barcelona, SpainBiochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, CIBERehd, Barcelona, SpainBiochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, CIBERehd, Barcelona, SpainDepartment of Biomedicine, University of Barcelona, Barcelona, SpainVall d’Hebron Institut of Research (VHIR), Barcelona, SpainInstitut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, Barcelona, SpainInstitució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, SpainWe review the apparent discrepancies between studies that report anti-inflammatory effects of cerium oxide nanoparticles (CeO2 NPs) through their reactive oxygen species-chelating properties and immunological studies highlighting their toxicity. We observe that several underappreciated parameters, such as aggregation size and degree of impurity, are critical determinants that need to be carefully addressed to better understand the NP biological effects in order to unleash their potential clinical benefits. This is because NPs can evolve toward different states, depending on the environment where they have been dispersed and how they have been dispersed. As a consequence, final characteristics of NPs can be very different from what was initially designed and produced in the laboratory. Thus, aggregation, corrosion, and interaction with extracellular matrix proteins critically modify NP features and fate. These modifications depend to a large extent on the characteristics of the biological media in which the NPs are dispersed. As a consequence, when reviewing the scientific literature, it seems that the aggregation state of NPs, which depends on the characteristics of the dispersing media, may be more significant than the composition or original size of the NPs. In this work, we focus on CeO2 NPs, which are reported sometimes to be protective and anti-inflammatory, and sometimes toxic and pro-inflammatory.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00970/fullnanoparticlescerium oxidenanoparticle evolutionnanoparticle agglomerationion leachingantioxidant activity |
| spellingShingle | Eudald Casals Muriel F. Gusta Jordi Piella Gregori Casals Wladimiro Jiménez Wladimiro Jiménez Victor Puntes Victor Puntes Victor Puntes Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide Frontiers in Immunology nanoparticles cerium oxide nanoparticle evolution nanoparticle agglomeration ion leaching antioxidant activity |
| title | Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide |
| title_full | Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide |
| title_fullStr | Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide |
| title_full_unstemmed | Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide |
| title_short | Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide |
| title_sort | intrinsic and extrinsic properties affecting innate immune responses to nanoparticles the case of cerium oxide |
| topic | nanoparticles cerium oxide nanoparticle evolution nanoparticle agglomeration ion leaching antioxidant activity |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00970/full |
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