A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension
Pulmonary arterial hypertension is a severe, progressive disease in children, that causes right ventricular dysfunction over time. Tissue motion annular displacement is a novel speckle-tracking derived echocardiographic parameter used in assessing ventricular function. The aim of our study was to de...
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MDPI AG
2022-05-01
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| Online Access: | https://www.mdpi.com/2076-3417/12/11/5494 |
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| author | Iolanda Muntean Mihaela Melinte Amalia Făgărășan Carmen Corina Șuteu Rodica Togănel |
| author_facet | Iolanda Muntean Mihaela Melinte Amalia Făgărășan Carmen Corina Șuteu Rodica Togănel |
| author_sort | Iolanda Muntean |
| collection | DOAJ |
| description | Pulmonary arterial hypertension is a severe, progressive disease in children, that causes right ventricular dysfunction over time. Tissue motion annular displacement is a novel speckle-tracking derived echocardiographic parameter used in assessing ventricular function. The aim of our study was to determine the prognostic value of this echocardiographic parameter in children with pulmonary arterial hypertension. We conducted a case-control study by assessing twenty children with pulmonary arterial hypertension (idiopathic or secondary) and twenty age- and sex-matched controls, using clinical (WHO functional class, 6-min walking test), laboratory (brain natriuretic peptide level) and echocardiographic parameters (conventional and speckle-tracking derived tissue motion annular displacement) at enrolment and after one year of follow-up. According to their WHO functional class altering after one year, the pulmonary arterial hypertension patients were divided into two groups: non-worsening (eleven) and worsening (nine). The conventional echocardiographic parameters and all measured tricuspid tissue motion annular displacement indices (lateral, septal, midpoint and midpoint fractional displacement—TMADm%) were significantly lower in both pulmonary arterial hypertension groups (non-worsening and worsening) compared to controls. Comparing the worsening and non-worsening groups, only the TMADm% and brain natriuretic peptide level was significantly lower in worsening in comparison with non-worsening pulmonary arterial hypertension children (<i>p</i> = 0.010 and <i>p</i> = 0.018, respectively). In receiver-operating characteristic curve analysis, we found a cut-off value of 16.15% for TMADm% and a cut-off value of 34.35 pg/mL for the brain natriuretic peptide level that can predict worsening in pulmonary arterial hypertension children. In conclusion, tricuspid annulus midpoint fractional displacement, an angle-dependent speckle-tracking derived parameter, could be a good additional parameter in the assessment of the longitudinal right ventricular systolic function and in prediction of clinical worsening in children with pulmonary arterial hypertension. |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T01:31:02Z |
| publishDate | 2022-05-01 |
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| series | Applied Sciences |
| spelling | doaj.art-d1e6e7c29fa040c888a388f4e4bc74392023-11-23T13:42:42ZengMDPI AGApplied Sciences2076-34172022-05-011211549410.3390/app12115494A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial HypertensionIolanda Muntean0Mihaela Melinte1Amalia Făgărășan2Carmen Corina Șuteu3Rodica Togănel4Clinic of Paediatric Cardiology, Emergency Institute for Cardiovascular and Transplant Diseases of Târgu Mureș, University of Medicine Pharmacy Sciences and Technology “George Emil Palade”, 540142 Târgu Mureș, RomaniaLaboratory Department, Emergency Institute for Cardiovascular and Transplant Diseases of Târgu Mureș, 540136 Târgu Mureș, RomaniaClinic of Paediatric Cardiology, Emergency Institute for Cardiovascular and Transplant Diseases of Târgu Mureș, University of Medicine Pharmacy Sciences and Technology “George Emil Palade”, 540142 Târgu Mureș, RomaniaClinic of Paediatric Cardiology, Emergency Institute for Cardiovascular and Transplant Diseases of Târgu Mureș, 540136 Târgu Mureș, RomaniaClinic of Paediatric Cardiology, Emergency Institute for Cardiovascular and Transplant Diseases of Târgu Mureș, University of Medicine Pharmacy Sciences and Technology “George Emil Palade”, 540142 Târgu Mureș, RomaniaPulmonary arterial hypertension is a severe, progressive disease in children, that causes right ventricular dysfunction over time. Tissue motion annular displacement is a novel speckle-tracking derived echocardiographic parameter used in assessing ventricular function. The aim of our study was to determine the prognostic value of this echocardiographic parameter in children with pulmonary arterial hypertension. We conducted a case-control study by assessing twenty children with pulmonary arterial hypertension (idiopathic or secondary) and twenty age- and sex-matched controls, using clinical (WHO functional class, 6-min walking test), laboratory (brain natriuretic peptide level) and echocardiographic parameters (conventional and speckle-tracking derived tissue motion annular displacement) at enrolment and after one year of follow-up. According to their WHO functional class altering after one year, the pulmonary arterial hypertension patients were divided into two groups: non-worsening (eleven) and worsening (nine). The conventional echocardiographic parameters and all measured tricuspid tissue motion annular displacement indices (lateral, septal, midpoint and midpoint fractional displacement—TMADm%) were significantly lower in both pulmonary arterial hypertension groups (non-worsening and worsening) compared to controls. Comparing the worsening and non-worsening groups, only the TMADm% and brain natriuretic peptide level was significantly lower in worsening in comparison with non-worsening pulmonary arterial hypertension children (<i>p</i> = 0.010 and <i>p</i> = 0.018, respectively). In receiver-operating characteristic curve analysis, we found a cut-off value of 16.15% for TMADm% and a cut-off value of 34.35 pg/mL for the brain natriuretic peptide level that can predict worsening in pulmonary arterial hypertension children. In conclusion, tricuspid annulus midpoint fractional displacement, an angle-dependent speckle-tracking derived parameter, could be a good additional parameter in the assessment of the longitudinal right ventricular systolic function and in prediction of clinical worsening in children with pulmonary arterial hypertension.https://www.mdpi.com/2076-3417/12/11/5494right ventriclespeckle-trackingtricuspid tissue motion annular displacementpulmonary arterial hypertensionchildren |
| spellingShingle | Iolanda Muntean Mihaela Melinte Amalia Făgărășan Carmen Corina Șuteu Rodica Togănel A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension Applied Sciences right ventricle speckle-tracking tricuspid tissue motion annular displacement pulmonary arterial hypertension children |
| title | A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension |
| title_full | A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension |
| title_fullStr | A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension |
| title_full_unstemmed | A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension |
| title_short | A Novel Speckle-Tracking Echocardiography Derived Parameter That Predicts Clinical Worsening in Children with Pulmonary Arterial Hypertension |
| title_sort | novel speckle tracking echocardiography derived parameter that predicts clinical worsening in children with pulmonary arterial hypertension |
| topic | right ventricle speckle-tracking tricuspid tissue motion annular displacement pulmonary arterial hypertension children |
| url | https://www.mdpi.com/2076-3417/12/11/5494 |
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