Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysis
Abstract Background We aimed to systematically compare Major Adverse Cardiac Events (MACEs) and mortality following Percutaneous Coronary Intervention (PCI) in patients with and without Chronic Obstructive Pulmonary Diseases (COPD) through a meta-analysis. Methods Electronic databases (Cochrane libr...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-07-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0622-2 |
| _version_ | 1828786224442114048 |
|---|---|
| author | Pravesh Kumar Bundhun Chakshu Gupta Guang Ma Xu |
| author_facet | Pravesh Kumar Bundhun Chakshu Gupta Guang Ma Xu |
| author_sort | Pravesh Kumar Bundhun |
| collection | DOAJ |
| description | Abstract Background We aimed to systematically compare Major Adverse Cardiac Events (MACEs) and mortality following Percutaneous Coronary Intervention (PCI) in patients with and without Chronic Obstructive Pulmonary Diseases (COPD) through a meta-analysis. Methods Electronic databases (Cochrane library, EMBASE and Medline/PubMed) were searched for English publications comparing in-hospital and long-term MACEs and mortality following PCI in patients with a past medical history of COPD. Statistical analysis was carried out by Revman 5.3 whereby Odds Ratio (OR) and 95% Confidence Intervals (CI) were considered the relevant parameters. Results A total number of 72,969 patients were included (7518 patients with COPD and 65,451 patients without COPD). Results of this analysis showed that in-hospital MACEs were significantly higher in the COPD group with OR: 1.40, 95% CI: 1.19–1.65; P = 0.0001, I2 = 0%. Long-term MACEs were still significantly higher in the COPD group with OR: 1.58, 95% CI: 1.38–1.81; P = 0.00001, I2 = 29%. Similarly, in-hospital and long-term mortality were significantly higher in patients with COPD, with OR: 2.25, 95% CI: 1.78–2.85; P = 0.00001, I2 = 0% and OR: 2.22, 95% CI: 1.33–3.71; P = 0.002, I2 = 97% respectively. However, the result for the long-term death was highly heterogeneous. Conclusion Since in-hospital and long-term MACEs and mortality were significantly higher following PCI in patients with versus without COPD, COPD should be considered a risk factor for the development of adverse clinical outcomes following PCI. However, the result for the long-term mortality was highly heterogeneous warranting further analysis. |
| first_indexed | 2024-12-12T00:07:33Z |
| format | Article |
| id | doaj.art-d1e6fc0f418e4f60b673ac85036d0f97 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-12T00:07:33Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-d1e6fc0f418e4f60b673ac85036d0f972022-12-22T00:45:05ZengBMCBMC Cardiovascular Disorders1471-22612017-07-0117111310.1186/s12872-017-0622-2Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysisPravesh Kumar Bundhun0Chakshu Gupta1Guang Ma Xu2Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous RegionAbstract Background We aimed to systematically compare Major Adverse Cardiac Events (MACEs) and mortality following Percutaneous Coronary Intervention (PCI) in patients with and without Chronic Obstructive Pulmonary Diseases (COPD) through a meta-analysis. Methods Electronic databases (Cochrane library, EMBASE and Medline/PubMed) were searched for English publications comparing in-hospital and long-term MACEs and mortality following PCI in patients with a past medical history of COPD. Statistical analysis was carried out by Revman 5.3 whereby Odds Ratio (OR) and 95% Confidence Intervals (CI) were considered the relevant parameters. Results A total number of 72,969 patients were included (7518 patients with COPD and 65,451 patients without COPD). Results of this analysis showed that in-hospital MACEs were significantly higher in the COPD group with OR: 1.40, 95% CI: 1.19–1.65; P = 0.0001, I2 = 0%. Long-term MACEs were still significantly higher in the COPD group with OR: 1.58, 95% CI: 1.38–1.81; P = 0.00001, I2 = 29%. Similarly, in-hospital and long-term mortality were significantly higher in patients with COPD, with OR: 2.25, 95% CI: 1.78–2.85; P = 0.00001, I2 = 0% and OR: 2.22, 95% CI: 1.33–3.71; P = 0.002, I2 = 97% respectively. However, the result for the long-term death was highly heterogeneous. Conclusion Since in-hospital and long-term MACEs and mortality were significantly higher following PCI in patients with versus without COPD, COPD should be considered a risk factor for the development of adverse clinical outcomes following PCI. However, the result for the long-term mortality was highly heterogeneous warranting further analysis.http://link.springer.com/article/10.1186/s12872-017-0622-2Chronic obstructive pulmonary diseasesPercutaneous coronary interventionMortalityMajor adverse cardiac events |
| spellingShingle | Pravesh Kumar Bundhun Chakshu Gupta Guang Ma Xu Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysis BMC Cardiovascular Disorders Chronic obstructive pulmonary diseases Percutaneous coronary intervention Mortality Major adverse cardiac events |
| title | Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysis |
| title_full | Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysis |
| title_fullStr | Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysis |
| title_full_unstemmed | Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysis |
| title_short | Major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention: a systematic review and meta-analysis |
| title_sort | major adverse cardiac events and mortality in chronic obstructive pulmonary disease following percutaneous coronary intervention a systematic review and meta analysis |
| topic | Chronic obstructive pulmonary diseases Percutaneous coronary intervention Mortality Major adverse cardiac events |
| url | http://link.springer.com/article/10.1186/s12872-017-0622-2 |
| work_keys_str_mv | AT praveshkumarbundhun majoradversecardiaceventsandmortalityinchronicobstructivepulmonarydiseasefollowingpercutaneouscoronaryinterventionasystematicreviewandmetaanalysis AT chakshugupta majoradversecardiaceventsandmortalityinchronicobstructivepulmonarydiseasefollowingpercutaneouscoronaryinterventionasystematicreviewandmetaanalysis AT guangmaxu majoradversecardiaceventsandmortalityinchronicobstructivepulmonarydiseasefollowingpercutaneouscoronaryinterventionasystematicreviewandmetaanalysis |