Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature
This report illustrates a Parkinson’s disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with h...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-11-01
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| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123217301042 |
| _version_ | 1828976453347180544 |
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| author | Sara Palermo Rosalba Morese Maurizio Zibetti Francesca Dematteis Stefano Sirgiovanni Mario Stanziano Maria Consuelo Valentini Leonardo Lopiano |
| author_facet | Sara Palermo Rosalba Morese Maurizio Zibetti Francesca Dematteis Stefano Sirgiovanni Mario Stanziano Maria Consuelo Valentini Leonardo Lopiano |
| author_sort | Sara Palermo |
| collection | DOAJ |
| description | This report illustrates a Parkinson’s disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with hypothesis on the role of response-inhibition disabilities in the arising of impulsivity in PD, the patient completely failed the go-nogo task. Moreover, fMRI acquisition revealed absent task-sensitive activity in the anterior cingulate cortex, medial prefrontal, and orbitofrontal cortices for the contrast nogo versus go, which signifying that a hypo-function of this network could be associated with ICD. A fronto-striatal and cingulo-frontal dysfunction may reflect impairment in metacognitive-executive abilities (such as response-inhibition, action monitoring, and error awareness) and promote compulsive repetition of behavior. Response-inhibition tasks may be useful in PD post-diagnostic phase, to better identify individuals at risk of developing ICD with dopaminergic medication. |
| first_indexed | 2024-12-14T14:38:32Z |
| format | Article |
| id | doaj.art-d1e782caf46746f7af189e8dc830c937 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 2090-1224 |
| language | English |
| last_indexed | 2024-12-14T14:38:32Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-d1e782caf46746f7af189e8dc830c9372022-12-21T22:57:30ZengElsevierJournal of Advanced Research2090-12322090-12242017-11-018671371610.1016/j.jare.2017.09.004Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literatureSara Palermo0Rosalba Morese1Maurizio Zibetti2Francesca Dematteis3Stefano Sirgiovanni4Mario Stanziano5Maria Consuelo Valentini6Leonardo Lopiano7Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, ItalyDepartment of Psychology, University of Turin, Via Verdi 10, 10123 Turin, ItalyDepartment of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, ItalyDepartment of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, ItalyAzienda Ospedaliera Universitaria “Città della Salute e della Scienza di Torino”, Department of Neuroradiology, Corso Bramante 88/90, 10126 Turin, ItalyAzienda Ospedaliera Universitaria “Città della Salute e della Scienza di Torino”, Department of Neuroradiology, Corso Bramante 88/90, 10126 Turin, ItalyAzienda Ospedaliera Universitaria “Città della Salute e della Scienza di Torino”, Department of Neuroradiology, Corso Bramante 88/90, 10126 Turin, ItalyDepartment of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, ItalyThis report illustrates a Parkinson’s disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with hypothesis on the role of response-inhibition disabilities in the arising of impulsivity in PD, the patient completely failed the go-nogo task. Moreover, fMRI acquisition revealed absent task-sensitive activity in the anterior cingulate cortex, medial prefrontal, and orbitofrontal cortices for the contrast nogo versus go, which signifying that a hypo-function of this network could be associated with ICD. A fronto-striatal and cingulo-frontal dysfunction may reflect impairment in metacognitive-executive abilities (such as response-inhibition, action monitoring, and error awareness) and promote compulsive repetition of behavior. Response-inhibition tasks may be useful in PD post-diagnostic phase, to better identify individuals at risk of developing ICD with dopaminergic medication.http://www.sciencedirect.com/science/article/pii/S2090123217301042Parkinson’s diseaseICDResponse-inhibitionAction monitoringfMRIACC |
| spellingShingle | Sara Palermo Rosalba Morese Maurizio Zibetti Francesca Dematteis Stefano Sirgiovanni Mario Stanziano Maria Consuelo Valentini Leonardo Lopiano Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature Journal of Advanced Research Parkinson’s disease ICD Response-inhibition Action monitoring fMRI ACC |
| title | Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature |
| title_full | Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature |
| title_fullStr | Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature |
| title_full_unstemmed | Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature |
| title_short | Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature |
| title_sort | impulse control disorder and response inhibition alterations in parkinson s disease a rare case of totally absent functionality of the medial prefrontal cortex and review of literature |
| topic | Parkinson’s disease ICD Response-inhibition Action monitoring fMRI ACC |
| url | http://www.sciencedirect.com/science/article/pii/S2090123217301042 |
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