Affective lability across psychosis spectrum disorders
AbstractBackground.Despite apparent clinical remission, individuals with psychotic disorders often experience significant impairments across functional domains. Thus, there is a need to search beyond management of core symptoms to optimize treatment outcomes. Affective dysregulation is considered a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2020-01-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933820000449/type/journal_article |
| _version_ | 1827995004465840128 |
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| author | Margrethe Collier Høegh Ingrid Melle Sofie R. Aminoff Jannicke Fjæra Laskemoen Camilla Bakkalia Büchmann Torill Ueland Trine Vik Lagerberg |
| author_facet | Margrethe Collier Høegh Ingrid Melle Sofie R. Aminoff Jannicke Fjæra Laskemoen Camilla Bakkalia Büchmann Torill Ueland Trine Vik Lagerberg |
| author_sort | Margrethe Collier Høegh |
| collection | DOAJ |
| description | AbstractBackground.Despite apparent clinical remission, individuals with psychotic disorders often experience significant impairments across functional domains. Thus, there is a need to search beyond management of core symptoms to optimize treatment outcomes. Affective dysregulation is considered a risk factor for poor clinical and functional outcomes in many mental disorders, but research investigating such features in psychosis, particularly in schizophrenia, is limited. We aimed to investigate the level of affective lability (AL) in participants with schizophrenia- and bipolar spectrum disorders (n = 222) compared to healthy controls (n = 140), as well as clinical correlates of AL in the diagnostic groups.Methods.The Affective Lability Scale (ALS-SF) was used to measure total score of AL and subscores covering the domains of anxiety/depression, depression/elation, and anger. An analysis of covariance was performed to compare the ALS-SF total score between groups, correcting for potential confounders, as well as standard multiple regression analyses for diagnosis-specific investigations of the relationship between AL and demographic and clinical features.Results.Both the schizophrenia- and bipolar spectrum group had significantly higher ALS-SF total score compared to controls (p < 0.001), and no significant differences between the patient groups were found. In the schizophrenia group, current psychotic and depressive symptoms were significantly and independently associated with AL (p = 0.012 and p = 0.024, respectively).Conclusions.The findings indicate that AL is elevated in psychotic disorders and that it transcends diagnostic boundaries. Further research into the causal relationship between psychotic and affective symptoms and AL, as well as its role as a potential therapeutic target in psychosis spectrum disorders, is warranted. |
| first_indexed | 2024-04-10T04:49:48Z |
| format | Article |
| id | doaj.art-d1e8f3f6ec27450590cb7eed843bbd76 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-04-10T04:49:48Z |
| publishDate | 2020-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-d1e8f3f6ec27450590cb7eed843bbd762023-03-09T12:33:57ZengCambridge University PressEuropean Psychiatry0924-93381778-35852020-01-016310.1192/j.eurpsy.2020.44Affective lability across psychosis spectrum disordersMargrethe Collier Høegh0https://orcid.org/0000-0001-6574-0382Ingrid Melle1Sofie R. Aminoff2Jannicke Fjæra Laskemoen3https://orcid.org/0000-0002-1628-519XCamilla Bakkalia Büchmann4https://orcid.org/0000-0002-7594-5493Torill Ueland5Trine Vik Lagerberg6https://orcid.org/0000-0003-3579-0789NORMENT, Centre for Research on Mental Disorders, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, NorwayNORMENT, Centre for Research on Mental Disorders, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, NorwayNORMENT, Centre for Research on Mental Disorders, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway Oslo University Hospital, Division of Mental Health and Addiction, Oslo, NorwayNORMENT, Centre for Research on Mental Disorders, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, NorwayNORMENT, Centre for Research on Mental Disorders, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, NorwayNORMENT, Centre for Research on Mental Disorders, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway Department of Psychology, University of Oslo, Oslo, NorwayNORMENT, Centre for Research on Mental Disorders, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, NorwayAbstractBackground.Despite apparent clinical remission, individuals with psychotic disorders often experience significant impairments across functional domains. Thus, there is a need to search beyond management of core symptoms to optimize treatment outcomes. Affective dysregulation is considered a risk factor for poor clinical and functional outcomes in many mental disorders, but research investigating such features in psychosis, particularly in schizophrenia, is limited. We aimed to investigate the level of affective lability (AL) in participants with schizophrenia- and bipolar spectrum disorders (n = 222) compared to healthy controls (n = 140), as well as clinical correlates of AL in the diagnostic groups.Methods.The Affective Lability Scale (ALS-SF) was used to measure total score of AL and subscores covering the domains of anxiety/depression, depression/elation, and anger. An analysis of covariance was performed to compare the ALS-SF total score between groups, correcting for potential confounders, as well as standard multiple regression analyses for diagnosis-specific investigations of the relationship between AL and demographic and clinical features.Results.Both the schizophrenia- and bipolar spectrum group had significantly higher ALS-SF total score compared to controls (p < 0.001), and no significant differences between the patient groups were found. In the schizophrenia group, current psychotic and depressive symptoms were significantly and independently associated with AL (p = 0.012 and p = 0.024, respectively).Conclusions.The findings indicate that AL is elevated in psychotic disorders and that it transcends diagnostic boundaries. Further research into the causal relationship between psychotic and affective symptoms and AL, as well as its role as a potential therapeutic target in psychosis spectrum disorders, is warranted.https://www.cambridge.org/core/product/identifier/S0924933820000449/type/journal_articleAffective labilityprevalencepsychosis spectrum disorders |
| spellingShingle | Margrethe Collier Høegh Ingrid Melle Sofie R. Aminoff Jannicke Fjæra Laskemoen Camilla Bakkalia Büchmann Torill Ueland Trine Vik Lagerberg Affective lability across psychosis spectrum disorders European Psychiatry Affective lability prevalence psychosis spectrum disorders |
| title | Affective lability across psychosis spectrum disorders |
| title_full | Affective lability across psychosis spectrum disorders |
| title_fullStr | Affective lability across psychosis spectrum disorders |
| title_full_unstemmed | Affective lability across psychosis spectrum disorders |
| title_short | Affective lability across psychosis spectrum disorders |
| title_sort | affective lability across psychosis spectrum disorders |
| topic | Affective lability prevalence psychosis spectrum disorders |
| url | https://www.cambridge.org/core/product/identifier/S0924933820000449/type/journal_article |
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