Investigation of Stent Prototypes for the Eustachian Tube in Human Donor Bodies
Chronic otitis media is often connected to Eustachian tube dysfunction. As successful treatment cannot be guaranteed with the currently available options, the aim is to develop a stent for the Eustachian tube (ET). Over the course of this development, different prototypes were generated and tested i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/6/743 |
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| author | Lena Rosenbusch Robert Schuon Tamara Wilfling Philipp Krüger Kerstin Lebahn Samuel John Olga Sahmel Niels Grabow Marko Schulze Andreas Wree Klaus-Peter Schmitz Tobias Stein Thomas Lenarz Gerrit Paasche |
| author_facet | Lena Rosenbusch Robert Schuon Tamara Wilfling Philipp Krüger Kerstin Lebahn Samuel John Olga Sahmel Niels Grabow Marko Schulze Andreas Wree Klaus-Peter Schmitz Tobias Stein Thomas Lenarz Gerrit Paasche |
| author_sort | Lena Rosenbusch |
| collection | DOAJ |
| description | Chronic otitis media is often connected to Eustachian tube dysfunction. As successful treatment cannot be guaranteed with the currently available options, the aim is to develop a stent for the Eustachian tube (ET). Over the course of this development, different prototypes were generated and tested in ex vivo experiments. Four different prototypes of an ET stent and one commercially available coronary stent were implanted in the ET of seven human donor bodies. The position of the stents was verified by cone beam CT. The implanted ETs were harvested, embedded in resin and ground at 200 µm steps. Resulting images of the single steps were used to generate 3D models. The 3D models were then evaluated regarding position of the stent in the ET, its diameters, amount of squeezing, orientation of the axes and other parameters. Virtual reconstruction of the implanted ET was successful in all cases and revealed one incorrect stent placement. The cross-section increased for all metal stents in direction from the isthmus towards the pharyngeal orifice of the ET. Depending on the individual design of the metal stents (open or closed design), the shape varied also between different positions along a single stent. In contrast, the cross-section area and shape remained constant along the polymeric prototype. With the current investigation, insight into the behavior of different prototypes of ET stents was gained, which can help in defining the specifications for the intended ET stent. |
| first_indexed | 2024-03-11T02:46:13Z |
| format | Article |
| id | doaj.art-d1ec1b5a6b2b401ead78c6637f9c25d7 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T02:46:13Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-d1ec1b5a6b2b401ead78c6637f9c25d72023-11-18T09:22:07ZengMDPI AGBioengineering2306-53542023-06-0110674310.3390/bioengineering10060743Investigation of Stent Prototypes for the Eustachian Tube in Human Donor BodiesLena Rosenbusch0Robert Schuon1Tamara Wilfling2Philipp Krüger3Kerstin Lebahn4Samuel John5Olga Sahmel6Niels Grabow7Marko Schulze8Andreas Wree9Klaus-Peter Schmitz10Tobias Stein11Thomas Lenarz12Gerrit Paasche13Department of Otorhinolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyDepartment of Otorhinolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyDepartment of Otorhinolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyBess Pro GmbH, Gustav-Krone-Str. 7, 14167 Berlin, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, GermanyHörSys GmbH, 30625 Hannover, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, GermanyInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, GermanyInstitute of Anatomy, Rostock University Medical Center, 18057 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, GermanyBess Pro GmbH, Gustav-Krone-Str. 7, 14167 Berlin, GermanyDepartment of Otorhinolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyDepartment of Otorhinolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, GermanyChronic otitis media is often connected to Eustachian tube dysfunction. As successful treatment cannot be guaranteed with the currently available options, the aim is to develop a stent for the Eustachian tube (ET). Over the course of this development, different prototypes were generated and tested in ex vivo experiments. Four different prototypes of an ET stent and one commercially available coronary stent were implanted in the ET of seven human donor bodies. The position of the stents was verified by cone beam CT. The implanted ETs were harvested, embedded in resin and ground at 200 µm steps. Resulting images of the single steps were used to generate 3D models. The 3D models were then evaluated regarding position of the stent in the ET, its diameters, amount of squeezing, orientation of the axes and other parameters. Virtual reconstruction of the implanted ET was successful in all cases and revealed one incorrect stent placement. The cross-section increased for all metal stents in direction from the isthmus towards the pharyngeal orifice of the ET. Depending on the individual design of the metal stents (open or closed design), the shape varied also between different positions along a single stent. In contrast, the cross-section area and shape remained constant along the polymeric prototype. With the current investigation, insight into the behavior of different prototypes of ET stents was gained, which can help in defining the specifications for the intended ET stent.https://www.mdpi.com/2306-5354/10/6/743eustachian tubenitinol stentpolymeric stent3D reconstructionhistologic evaluation |
| spellingShingle | Lena Rosenbusch Robert Schuon Tamara Wilfling Philipp Krüger Kerstin Lebahn Samuel John Olga Sahmel Niels Grabow Marko Schulze Andreas Wree Klaus-Peter Schmitz Tobias Stein Thomas Lenarz Gerrit Paasche Investigation of Stent Prototypes for the Eustachian Tube in Human Donor Bodies Bioengineering eustachian tube nitinol stent polymeric stent 3D reconstruction histologic evaluation |
| title | Investigation of Stent Prototypes for the Eustachian Tube in Human Donor Bodies |
| title_full | Investigation of Stent Prototypes for the Eustachian Tube in Human Donor Bodies |
| title_fullStr | Investigation of Stent Prototypes for the Eustachian Tube in Human Donor Bodies |
| title_full_unstemmed | Investigation of Stent Prototypes for the Eustachian Tube in Human Donor Bodies |
| title_short | Investigation of Stent Prototypes for the Eustachian Tube in Human Donor Bodies |
| title_sort | investigation of stent prototypes for the eustachian tube in human donor bodies |
| topic | eustachian tube nitinol stent polymeric stent 3D reconstruction histologic evaluation |
| url | https://www.mdpi.com/2306-5354/10/6/743 |
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