Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care
A stay in intensive care unit (ICU) exposes patients to a risk of carnitine deficiency. Moreover, acylated derivates of carnitine (acylcarnitines, AC) are biomarkers for metabolic mitochondrial dysfunction that have been linked to post-ICU disorders. This study aimed to describe the AC profile of su...
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/1122 |
| _version_ | 1797474188498305024 |
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| author | Anne-Françoise Rousseau Sarah Schmitz Etienne Cavalier Benoit Misset François Boemer |
| author_facet | Anne-Françoise Rousseau Sarah Schmitz Etienne Cavalier Benoit Misset François Boemer |
| author_sort | Anne-Françoise Rousseau |
| collection | DOAJ |
| description | A stay in intensive care unit (ICU) exposes patients to a risk of carnitine deficiency. Moreover, acylated derivates of carnitine (acylcarnitines, AC) are biomarkers for metabolic mitochondrial dysfunction that have been linked to post-ICU disorders. This study aimed to describe the AC profile of survivors of a prolonged ICU stay (≥7 days). Survivors enrolled in our post-ICU clinic between September 2020 and July 2021 were included. Blood analysis was routinely performed during the days after ICU discharge, focusing on metabolic markers and including AC profile. Serum AC concentrations were determined by LC-MS/MS and were compared to the reference ranges (RR) established from serum samples of 50 non-hospitalized Belgian adults aged from 18 to 81 years. A total 162 patients (65.4% males, age 67 (58.7–73) years) survived an ICU stay of 9.7 (7.1–19.3) days and were evaluated 5 (3–8) days after discharge. Their AC profile was significantly different compared to RR, mostly in terms of short chain AC: the sum of C3, C4 and C5 derivates reached 1.36 (0.98–1.99) and 0.86 (0.66–0.99) µmol/L respectively (<i>p</i> < 0.001). Free carnitine (C0) concentration of survivors (46.06 (35.04–56.35) µmol/L) was similar to RR (43.64 (36.43–52.96) µmol/L) (<i>p</i> = 0.55). C0 below percentile 2.5 of RR was observed in 6/162 (3.7%) survivors. Their total AC/C0 ratio was 0.33 (0.22–0.42). A ratio above 0.4 was observed in 45/162 (27.8%) patients. In ICU survivors, carnitine deficiency was rare, but AC profile was altered and AC/C0 ratio was abnormal in more than 25%. The value of AC profile as a marker of post-ICU dysmetabolism needs further investigations. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:26:35Z |
| publishDate | 2022-03-01 |
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| series | Nutrients |
| spelling | doaj.art-d1ef302b5035489da706ef2a884e8c2c2023-11-23T23:34:52ZengMDPI AGNutrients2072-66432022-03-01145112210.3390/nu14051122Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive CareAnne-Françoise Rousseau0Sarah Schmitz1Etienne Cavalier2Benoit Misset3François Boemer4Intensive Care Department and Burn Centre, University Hospital of Liège, University of Liège, 4000 Liège, BelgiumIntensive Care Department and Burn Centre, University Hospital of Liège, University of Liège, 4000 Liège, BelgiumClinical Chemistry Department, University Hospital of Liège, University of Liège, 4000 Liège, BelgiumIntensive Care Department and Burn Centre, University Hospital of Liège, University of Liège, 4000 Liège, BelgiumBiochemical Genetics Lab, Department of Human Genetics, University Hospital of Liège, University of Liège, 4000 Liège, BelgiumA stay in intensive care unit (ICU) exposes patients to a risk of carnitine deficiency. Moreover, acylated derivates of carnitine (acylcarnitines, AC) are biomarkers for metabolic mitochondrial dysfunction that have been linked to post-ICU disorders. This study aimed to describe the AC profile of survivors of a prolonged ICU stay (≥7 days). Survivors enrolled in our post-ICU clinic between September 2020 and July 2021 were included. Blood analysis was routinely performed during the days after ICU discharge, focusing on metabolic markers and including AC profile. Serum AC concentrations were determined by LC-MS/MS and were compared to the reference ranges (RR) established from serum samples of 50 non-hospitalized Belgian adults aged from 18 to 81 years. A total 162 patients (65.4% males, age 67 (58.7–73) years) survived an ICU stay of 9.7 (7.1–19.3) days and were evaluated 5 (3–8) days after discharge. Their AC profile was significantly different compared to RR, mostly in terms of short chain AC: the sum of C3, C4 and C5 derivates reached 1.36 (0.98–1.99) and 0.86 (0.66–0.99) µmol/L respectively (<i>p</i> < 0.001). Free carnitine (C0) concentration of survivors (46.06 (35.04–56.35) µmol/L) was similar to RR (43.64 (36.43–52.96) µmol/L) (<i>p</i> = 0.55). C0 below percentile 2.5 of RR was observed in 6/162 (3.7%) survivors. Their total AC/C0 ratio was 0.33 (0.22–0.42). A ratio above 0.4 was observed in 45/162 (27.8%) patients. In ICU survivors, carnitine deficiency was rare, but AC profile was altered and AC/C0 ratio was abnormal in more than 25%. The value of AC profile as a marker of post-ICU dysmetabolism needs further investigations.https://www.mdpi.com/2072-6643/14/5/1122carnitinecritical illnesssurvivorsmitochondrial dysfunctioncatabolismfatty acid metabolism |
| spellingShingle | Anne-Françoise Rousseau Sarah Schmitz Etienne Cavalier Benoit Misset François Boemer Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care Nutrients carnitine critical illness survivors mitochondrial dysfunction catabolism fatty acid metabolism |
| title | Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care |
| title_full | Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care |
| title_fullStr | Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care |
| title_full_unstemmed | Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care |
| title_short | Altered Serum Acylcarnitines Profile after a Prolonged Stay in Intensive Care |
| title_sort | altered serum acylcarnitines profile after a prolonged stay in intensive care |
| topic | carnitine critical illness survivors mitochondrial dysfunction catabolism fatty acid metabolism |
| url | https://www.mdpi.com/2072-6643/14/5/1122 |
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