Functional role of peripheral vasoconstriction: not only thermoregulation but much more
Peripheral vasoconstriction is a centrally mediated physiological effect known to play an important role in regulating body temperature by adjusting heat exchange with the external environment. However, peripheral vasoconstriction as a component of sympathetic activation also occurs following ex...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-09-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1632962206845-486777538.pdf |
| _version_ | 1811304509682483200 |
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| author | Eugene A. Kiyatkin |
| author_facet | Eugene A. Kiyatkin |
| author_sort | Eugene A. Kiyatkin |
| collection | DOAJ |
| description | Peripheral vasoconstriction is a centrally mediated
physiological effect known to play an important role in regulating body
temperature by adjusting heat exchange with the external environment. However,
peripheral vasoconstriction as a component of sympathetic activation also occurs
following exposure to various salient stimuli and during motivated behavior at
stable environmental temperatures. This review aims to consider available
evidence suggesting a significant contribution of this peripheral effect to
physiological increases in both brain temperature and entry of oxygen and glucose
into the brain’s extracellular space. While these effects are triggered by
neuronal activation, constriction of blood vessels in the skin and most internal
organs results in redistribution of blood from the peripheral to central domains,
thus dilating cerebral vessels, increasing global cerebral blood flow, and
enhancing the intra-brain entry of oxygen and glucose from arterial blood. This
powerful influence appears to determine the long duration of physiological
increases in both brain temperature and brain levels of glucose and oxygen and
their basic similarity across different brain structures. This work underscores
the tight interrelationship between the brain and periphery and a significant
contribution of cardiovascular effects in providing the enhanced inflow of oxygen
and glucose into brain tissue to prevent metabolic deficit during functional
neural activation. |
| first_indexed | 2024-04-13T08:08:25Z |
| format | Article |
| id | doaj.art-d1f0a2a8f5c1422c8c335b3fbf020dc0 |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-04-13T08:08:25Z |
| publishDate | 2021-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-d1f0a2a8f5c1422c8c335b3fbf020dc02022-12-22T02:55:06ZengIMR PressJournal of Integrative Neuroscience1757-448X2021-09-0120375576410.31083/j.jin20030801632962206845-486777538Functional role of peripheral vasoconstriction: not only thermoregulation but much moreEugene A. Kiyatkin0Behavioral Neuroscience Branch, National Institute on Drug Abuse–Intramural Research Program, National Institutes of Health, DHHS, Baltimore, MD 21224, USAPeripheral vasoconstriction is a centrally mediated physiological effect known to play an important role in regulating body temperature by adjusting heat exchange with the external environment. However, peripheral vasoconstriction as a component of sympathetic activation also occurs following exposure to various salient stimuli and during motivated behavior at stable environmental temperatures. This review aims to consider available evidence suggesting a significant contribution of this peripheral effect to physiological increases in both brain temperature and entry of oxygen and glucose into the brain’s extracellular space. While these effects are triggered by neuronal activation, constriction of blood vessels in the skin and most internal organs results in redistribution of blood from the peripheral to central domains, thus dilating cerebral vessels, increasing global cerebral blood flow, and enhancing the intra-brain entry of oxygen and glucose from arterial blood. This powerful influence appears to determine the long duration of physiological increases in both brain temperature and brain levels of glucose and oxygen and their basic similarity across different brain structures. This work underscores the tight interrelationship between the brain and periphery and a significant contribution of cardiovascular effects in providing the enhanced inflow of oxygen and glucose into brain tissue to prevent metabolic deficit during functional neural activation.https://jin.imrpress.com/fileup/1757-448X/PDF/1632962206845-486777538.pdfbrain temperaturebrain oxygenbrain glucoseneural activationperipheral vasoconstrictioncentral vasodilationhyperoxiahyperglycemiahypoxiarats |
| spellingShingle | Eugene A. Kiyatkin Functional role of peripheral vasoconstriction: not only thermoregulation but much more Journal of Integrative Neuroscience brain temperature brain oxygen brain glucose neural activation peripheral vasoconstriction central vasodilation hyperoxia hyperglycemia hypoxia rats |
| title | Functional role of peripheral vasoconstriction: not only thermoregulation but much more |
| title_full | Functional role of peripheral vasoconstriction: not only thermoregulation but much more |
| title_fullStr | Functional role of peripheral vasoconstriction: not only thermoregulation but much more |
| title_full_unstemmed | Functional role of peripheral vasoconstriction: not only thermoregulation but much more |
| title_short | Functional role of peripheral vasoconstriction: not only thermoregulation but much more |
| title_sort | functional role of peripheral vasoconstriction not only thermoregulation but much more |
| topic | brain temperature brain oxygen brain glucose neural activation peripheral vasoconstriction central vasodilation hyperoxia hyperglycemia hypoxia rats |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1632962206845-486777538.pdf |
| work_keys_str_mv | AT eugeneakiyatkin functionalroleofperipheralvasoconstrictionnotonlythermoregulationbutmuchmore |