Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent demethylation. Recent evidence has shown that...

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Bibliographic Details
Main Authors: Cheng Dong, Heng Zhang, Chao Xu, Cheryl H. Arrowsmith, Jinrong Min
Format: Article
Language:English
Published: International Union of Crystallography 2014-11-01
Series:IUCrJ
Subjects:
dioxygenases
histone demethylation
DNA/RNA demethylation
N6-methyladenosine
ALKBH5
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252514020922

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