Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases
L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms, especially in edible mushrooms. EGT is found to be highly accumulated in tissues that are susceptible to oxidative damage, and it has attracted extensive attention due to its powerful antioxidant activity and the tight relat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.850813/full |
| _version_ | 1818997411004022784 |
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| author | Tong-Tong Fu Tong-Tong Fu Liang Shen Liang Shen |
| author_facet | Tong-Tong Fu Tong-Tong Fu Liang Shen Liang Shen |
| author_sort | Tong-Tong Fu |
| collection | DOAJ |
| description | L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms, especially in edible mushrooms. EGT is found to be highly accumulated in tissues that are susceptible to oxidative damage, and it has attracted extensive attention due to its powerful antioxidant activity and the tight relationships of this natural product with various oxidative stress-related diseases. Herein, we 1) introduce the biological source and in vivo distribution of EGT; 2) review the currently available evidence concerning the relationships of EGT with diabetes, ischemia-reperfusion injury-related diseases like cardiovascular diseases and liver diseases, neurodegenerative diseases, and other diseases pathogenically associated with oxidative stress; 3) summarize the potential action mechanisms of EGT against these diseases; 4) discuss the advantages of EGT over other antioxidants; and 5) also propose several future research perspectives for EGT. These may help to promote the future application of this attractive natural antioxidant. |
| first_indexed | 2024-12-20T21:45:12Z |
| format | Article |
| id | doaj.art-d1f1d873c2eb47269c2be60075e16be2 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T21:45:12Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-d1f1d873c2eb47269c2be60075e16be22022-12-21T19:25:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-03-011310.3389/fphar.2022.850813850813Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related DiseasesTong-Tong Fu0Tong-Tong Fu1Liang Shen2Liang Shen3Institute of Biomedical Research, Shandong University of Technology, Zibo, ChinaShandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo Key Laboratory of New Drug Development of Neurodegenerative Diseases, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, ChinaInstitute of Biomedical Research, Shandong University of Technology, Zibo, ChinaShandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo Key Laboratory of New Drug Development of Neurodegenerative Diseases, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, ChinaL-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms, especially in edible mushrooms. EGT is found to be highly accumulated in tissues that are susceptible to oxidative damage, and it has attracted extensive attention due to its powerful antioxidant activity and the tight relationships of this natural product with various oxidative stress-related diseases. Herein, we 1) introduce the biological source and in vivo distribution of EGT; 2) review the currently available evidence concerning the relationships of EGT with diabetes, ischemia-reperfusion injury-related diseases like cardiovascular diseases and liver diseases, neurodegenerative diseases, and other diseases pathogenically associated with oxidative stress; 3) summarize the potential action mechanisms of EGT against these diseases; 4) discuss the advantages of EGT over other antioxidants; and 5) also propose several future research perspectives for EGT. These may help to promote the future application of this attractive natural antioxidant.https://www.frontiersin.org/articles/10.3389/fphar.2022.850813/fullL-ergothioneineantioxidantoxidative stressaction mechanismdisease |
| spellingShingle | Tong-Tong Fu Tong-Tong Fu Liang Shen Liang Shen Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases Frontiers in Pharmacology L-ergothioneine antioxidant oxidative stress action mechanism disease |
| title | Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases |
| title_full | Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases |
| title_fullStr | Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases |
| title_full_unstemmed | Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases |
| title_short | Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases |
| title_sort | ergothioneine as a natural antioxidant against oxidative stress related diseases |
| topic | L-ergothioneine antioxidant oxidative stress action mechanism disease |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.850813/full |
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