Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects
Abstract Bone defects are among the most common damages in human medicine. Due to limitations and challenges in the area of bone healing, the research field has turned into a hot topic discipline with direct clinical outcomes. Among several available modalities, scaffold-free cell sheet technology h...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03309-4 |
| _version_ | 1827970605599686656 |
|---|---|
| author | Behnaz Banimohamad-Shotorbani Sonia Fathi Karkan Reza Rahbarghazi Ahmad Mehdipour Seyedhosein Jarolmasjed Sepideh Saghati Hajar Shafaei |
| author_facet | Behnaz Banimohamad-Shotorbani Sonia Fathi Karkan Reza Rahbarghazi Ahmad Mehdipour Seyedhosein Jarolmasjed Sepideh Saghati Hajar Shafaei |
| author_sort | Behnaz Banimohamad-Shotorbani |
| collection | DOAJ |
| description | Abstract Bone defects are among the most common damages in human medicine. Due to limitations and challenges in the area of bone healing, the research field has turned into a hot topic discipline with direct clinical outcomes. Among several available modalities, scaffold-free cell sheet technology has opened novel avenues to yield efficient osteogenesis. It is suggested that the intact matrix secreted from cells can provide a unique microenvironment for the acceleration of osteoangiogenesis. To the best of our knowledge, cell sheet technology (CST) has been investigated in terms of several skeletal defects with promising outcomes. Here, we highlighted some recent advances associated with the application of CST for the recovery of craniomaxillofacial (CMF) in various preclinical settings. The regenerative properties of both single-layer and multilayer CST were assessed regarding fabrication methods and applications. It has been indicated that different forms of cell sheets are available for CMF engineering like those used for other hard tissues. By tackling current challenges, CST is touted as an effective and alternative therapeutic option for CMF bone regeneration. |
| first_indexed | 2024-04-09T18:56:24Z |
| format | Article |
| id | doaj.art-d1f328c8156244fd8edba1969f2fcfc6 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-09T18:56:24Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-d1f328c8156244fd8edba1969f2fcfc62023-04-09T11:09:52ZengBMCStem Cell Research & Therapy1757-65122023-04-0114112110.1186/s13287-023-03309-4Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defectsBehnaz Banimohamad-Shotorbani0Sonia Fathi Karkan1Reza Rahbarghazi2Ahmad Mehdipour3Seyedhosein Jarolmasjed4Sepideh Saghati5Hajar Shafaei6Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesDepartment of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesDepartment of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesDepartment of Clinical Sciences, Faculty of Veterinary Medicine, University of TabrizDepartment of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesAbstract Bone defects are among the most common damages in human medicine. Due to limitations and challenges in the area of bone healing, the research field has turned into a hot topic discipline with direct clinical outcomes. Among several available modalities, scaffold-free cell sheet technology has opened novel avenues to yield efficient osteogenesis. It is suggested that the intact matrix secreted from cells can provide a unique microenvironment for the acceleration of osteoangiogenesis. To the best of our knowledge, cell sheet technology (CST) has been investigated in terms of several skeletal defects with promising outcomes. Here, we highlighted some recent advances associated with the application of CST for the recovery of craniomaxillofacial (CMF) in various preclinical settings. The regenerative properties of both single-layer and multilayer CST were assessed regarding fabrication methods and applications. It has been indicated that different forms of cell sheets are available for CMF engineering like those used for other hard tissues. By tackling current challenges, CST is touted as an effective and alternative therapeutic option for CMF bone regeneration.https://doi.org/10.1186/s13287-023-03309-4Cell sheet technologyCraniomaxillofacial defectsBone regenerationTissue engineering |
| spellingShingle | Behnaz Banimohamad-Shotorbani Sonia Fathi Karkan Reza Rahbarghazi Ahmad Mehdipour Seyedhosein Jarolmasjed Sepideh Saghati Hajar Shafaei Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects Stem Cell Research & Therapy Cell sheet technology Craniomaxillofacial defects Bone regeneration Tissue engineering |
| title | Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects |
| title_full | Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects |
| title_fullStr | Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects |
| title_full_unstemmed | Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects |
| title_short | Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects |
| title_sort | application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects |
| topic | Cell sheet technology Craniomaxillofacial defects Bone regeneration Tissue engineering |
| url | https://doi.org/10.1186/s13287-023-03309-4 |
| work_keys_str_mv | AT behnazbanimohamadshotorbani applicationofmesenchymalstemcellsheetforregenerationofcraniomaxillofacialbonedefects AT soniafathikarkan applicationofmesenchymalstemcellsheetforregenerationofcraniomaxillofacialbonedefects AT rezarahbarghazi applicationofmesenchymalstemcellsheetforregenerationofcraniomaxillofacialbonedefects AT ahmadmehdipour applicationofmesenchymalstemcellsheetforregenerationofcraniomaxillofacialbonedefects AT seyedhoseinjarolmasjed applicationofmesenchymalstemcellsheetforregenerationofcraniomaxillofacialbonedefects AT sepidehsaghati applicationofmesenchymalstemcellsheetforregenerationofcraniomaxillofacialbonedefects AT hajarshafaei applicationofmesenchymalstemcellsheetforregenerationofcraniomaxillofacialbonedefects |