Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei
The nuclear pore complex (NPC) is the sole gateway for molecular transport between the nucleus and the cytoplasm in eukaryotes. The NPC is composed of approximately 30 different kinds of protein components called nucleoporins. The functional structure of the NPC is highly conserved among various euk...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Communicative & Integrative Biology |
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| Online Access: | http://dx.doi.org/10.1080/19420889.2017.1384890 |
| _version_ | 1818606342489767936 |
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| author | Masaaki Iwamoto Yasushi Hiraoka Tokuko Haraguchi |
| author_facet | Masaaki Iwamoto Yasushi Hiraoka Tokuko Haraguchi |
| author_sort | Masaaki Iwamoto |
| collection | DOAJ |
| description | The nuclear pore complex (NPC) is the sole gateway for molecular transport between the nucleus and the cytoplasm in eukaryotes. The NPC is composed of approximately 30 different kinds of protein components called nucleoporins. The functional structure of the NPC is highly conserved among various eukaryotes. However, the exact mechanisms by which many of the nucleoporins exert their specific functions still remain unclear. The single cell ciliate Tetrahymena has two functionally distinct nuclei, a macronucleus and a micronucleus, and we have discovered that these two nuclei have compositionally distinct NPCs. We initially identified four nucleus-specific Nup98-s and demonstrated that they are required for macronucleus- and micronucleus-specific nuclear transport. More recently we identified two nucleus-specific paralogs of Nup214 and Nup153 and two nucleus-specific transmembrane proteins Pom121 and Pom82. Our findings argue that Nup214, Nup153, and Pom121/Pom82 also act as key molecules for transport machineries to differentiate the two functionally distinct nuclei present in this organism. |
| first_indexed | 2024-12-16T14:09:20Z |
| format | Article |
| id | doaj.art-d1f32e5b0e21458ca5796702c369036f |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-12-16T14:09:20Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-d1f32e5b0e21458ca5796702c369036f2022-12-21T22:28:50ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892018-01-0111110.1080/19420889.2017.13848901384890Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nucleiMasaaki Iwamoto0Yasushi Hiraoka1Tokuko Haraguchi2Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology (NICT)Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology (NICT)Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology (NICT)The nuclear pore complex (NPC) is the sole gateway for molecular transport between the nucleus and the cytoplasm in eukaryotes. The NPC is composed of approximately 30 different kinds of protein components called nucleoporins. The functional structure of the NPC is highly conserved among various eukaryotes. However, the exact mechanisms by which many of the nucleoporins exert their specific functions still remain unclear. The single cell ciliate Tetrahymena has two functionally distinct nuclei, a macronucleus and a micronucleus, and we have discovered that these two nuclei have compositionally distinct NPCs. We initially identified four nucleus-specific Nup98-s and demonstrated that they are required for macronucleus- and micronucleus-specific nuclear transport. More recently we identified two nucleus-specific paralogs of Nup214 and Nup153 and two nucleus-specific transmembrane proteins Pom121 and Pom82. Our findings argue that Nup214, Nup153, and Pom121/Pom82 also act as key molecules for transport machineries to differentiate the two functionally distinct nuclei present in this organism.http://dx.doi.org/10.1080/19420889.2017.1384890nuclear pore complexnucleoporinmacronucleus, micronucleusciliateTetrahymena thermophila |
| spellingShingle | Masaaki Iwamoto Yasushi Hiraoka Tokuko Haraguchi Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei Communicative & Integrative Biology nuclear pore complex nucleoporin macronucleus, micronucleus ciliate Tetrahymena thermophila |
| title | Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei |
| title_full | Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei |
| title_fullStr | Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei |
| title_full_unstemmed | Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei |
| title_short | Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei |
| title_sort | newly found tetrahymena nucleoporins nup214 nup153 and pom121 pom82 differentiate nuclear pore complexes of functionally distinct nuclei |
| topic | nuclear pore complex nucleoporin macronucleus, micronucleus ciliate Tetrahymena thermophila |
| url | http://dx.doi.org/10.1080/19420889.2017.1384890 |
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