Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis
Abstract Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive connectivity throughout the central nervous system (CNS). Using a model of autoimmune demyelination that exhibits CNS-infiltrating immune c...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Acta Neuropathologica Communications |
| Online Access: | https://doi.org/10.1186/s40478-022-01391-y |
| _version_ | 1828813418070540288 |
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| author | Gabrielle M. Mey Kirsten S. Evonuk McKenzie K. Chappell Laura M. Wolfe Rupesh Singh Julia C. Batoki Minzhong Yu Neal S. Peachey Bela Anand-Apte Robert Bermel Daniel Ontaneda Kunio Nakamura Kedar R. Mahajan Tara M. DeSilva |
| author_facet | Gabrielle M. Mey Kirsten S. Evonuk McKenzie K. Chappell Laura M. Wolfe Rupesh Singh Julia C. Batoki Minzhong Yu Neal S. Peachey Bela Anand-Apte Robert Bermel Daniel Ontaneda Kunio Nakamura Kedar R. Mahajan Tara M. DeSilva |
| author_sort | Gabrielle M. Mey |
| collection | DOAJ |
| description | Abstract Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive connectivity throughout the central nervous system (CNS). Using a model of autoimmune demyelination that exhibits CNS-infiltrating immune cells in both spinal cord white matter and optic nerve, we sought to evaluate neurodegenerative changes due to lesions affecting the spino- and retino-thalamic pathways. We found comparable axonal loss in spinal cord white matter and optic nerve during the acute phase of disease consistent with synaptic loss, but not neuronal cell body loss in the thalamic nuclei that receive input from these discrete pathways. Loss of spinal cord neurons or retinal ganglion cells retrograde to their respective axons was not observed until the chronic phase of disease, where optical coherence tomography (OCT) documented reduced inner retinal thickness. In patients with relapsing–remitting MS without a history of optic neuritis, OCT measures of inner retinal volume correlated with retino-thalamic (lateral geniculate nucleus) and spino-thalamic (ventral posterior nucleus) volume as well as neuroperformance measures. These data suggest retinal imaging may serve as an important noninvasive predictor of neurodegeneration in MS. |
| first_indexed | 2024-12-12T09:59:37Z |
| format | Article |
| id | doaj.art-d1f51e11e09742c58a6739f3748c0f61 |
| institution | Directory Open Access Journal |
| issn | 2051-5960 |
| language | English |
| last_indexed | 2024-12-12T09:59:37Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Neuropathologica Communications |
| spelling | doaj.art-d1f51e11e09742c58a6739f3748c0f612022-12-22T00:28:01ZengBMCActa Neuropathologica Communications2051-59602022-06-0110111810.1186/s40478-022-01391-yVisual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosisGabrielle M. Mey0Kirsten S. Evonuk1McKenzie K. Chappell2Laura M. Wolfe3Rupesh Singh4Julia C. Batoki5Minzhong Yu6Neal S. Peachey7Bela Anand-Apte8Robert Bermel9Daniel Ontaneda10Kunio Nakamura11Kedar R. Mahajan12Tara M. DeSilva13Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve UniversityDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve UniversityDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve UniversityDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve UniversityCole Eye Institute, Cleveland Clinic FoundationCole Eye Institute, Cleveland Clinic FoundationCole Eye Institute, Cleveland Clinic FoundationCole Eye Institute, Cleveland Clinic FoundationCole Eye Institute, Cleveland Clinic FoundationMellen Center for MS Treatment and Research, Neurological Institute, Cleveland Clinic FoundationMellen Center for MS Treatment and Research, Neurological Institute, Cleveland Clinic FoundationDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic FoundationDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve UniversityDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve UniversityAbstract Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive connectivity throughout the central nervous system (CNS). Using a model of autoimmune demyelination that exhibits CNS-infiltrating immune cells in both spinal cord white matter and optic nerve, we sought to evaluate neurodegenerative changes due to lesions affecting the spino- and retino-thalamic pathways. We found comparable axonal loss in spinal cord white matter and optic nerve during the acute phase of disease consistent with synaptic loss, but not neuronal cell body loss in the thalamic nuclei that receive input from these discrete pathways. Loss of spinal cord neurons or retinal ganglion cells retrograde to their respective axons was not observed until the chronic phase of disease, where optical coherence tomography (OCT) documented reduced inner retinal thickness. In patients with relapsing–remitting MS without a history of optic neuritis, OCT measures of inner retinal volume correlated with retino-thalamic (lateral geniculate nucleus) and spino-thalamic (ventral posterior nucleus) volume as well as neuroperformance measures. These data suggest retinal imaging may serve as an important noninvasive predictor of neurodegeneration in MS.https://doi.org/10.1186/s40478-022-01391-y |
| spellingShingle | Gabrielle M. Mey Kirsten S. Evonuk McKenzie K. Chappell Laura M. Wolfe Rupesh Singh Julia C. Batoki Minzhong Yu Neal S. Peachey Bela Anand-Apte Robert Bermel Daniel Ontaneda Kunio Nakamura Kedar R. Mahajan Tara M. DeSilva Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis Acta Neuropathologica Communications |
| title | Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis |
| title_full | Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis |
| title_fullStr | Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis |
| title_full_unstemmed | Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis |
| title_short | Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis |
| title_sort | visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis |
| url | https://doi.org/10.1186/s40478-022-01391-y |
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