Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
The aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2012-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&tlng=en |
| _version_ | 1828425662310907904 |
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| author | Alexandre Luis Parize Hellen Karine Stulzer Mauro César Marghetti Laranjeira Inês Maria da Costa Brighente Tereza Cristina Rozone de Souza |
| author_facet | Alexandre Luis Parize Hellen Karine Stulzer Mauro César Marghetti Laranjeira Inês Maria da Costa Brighente Tereza Cristina Rozone de Souza |
| author_sort | Alexandre Luis Parize |
| collection | DOAJ |
| description | The aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation. |
| first_indexed | 2024-12-10T16:35:25Z |
| format | Article |
| id | doaj.art-d1f75797a6a64e77a4c9c0a39db19c87 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-10T16:35:25Z |
| publishDate | 2012-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-d1f75797a6a64e77a4c9c0a39db19c872022-12-22T01:41:27ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642012-01-013561127113210.1590/S0100-40422012000600011S0100-40422012000600011Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray dryingAlexandre Luis Parize0Hellen Karine Stulzer1Mauro César Marghetti Laranjeira2Inês Maria da Costa Brighente3Tereza Cristina Rozone de Souza4Universidade de BrasíliaUniversidade Federal de Santa CatarinaUniversidade Federal de Santa CatarinaUniversidade Federal de Santa CatarinaUniversidade Federal de Santa CatarinaThe aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&tlng=enchitosancurcuminspray drying |
| spellingShingle | Alexandre Luis Parize Hellen Karine Stulzer Mauro César Marghetti Laranjeira Inês Maria da Costa Brighente Tereza Cristina Rozone de Souza Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying Química Nova chitosan curcumin spray drying |
| title | Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying |
| title_full | Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying |
| title_fullStr | Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying |
| title_full_unstemmed | Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying |
| title_short | Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying |
| title_sort | evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying |
| topic | chitosan curcumin spray drying |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&tlng=en |
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