Testosterone is an endogenous regulator of BAFF and splenic B cell number

Testosterone is an endogenous regulator of BAFF and splenic B cell number

Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter...

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Dades bibliogràfiques
Autors principals: Anna S. Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B. Buechler, Steve Lianoglou, Varun N. Kapoor, Maria E. Johansson, Johan B. Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T. Porse, Antonius G. Rolink, Hans Nissbrandt, Shannon J. Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C. I. Karlsson, Åsa Tivesten
Format: Article
Idioma:English
Publicat: Nature Portfolio 2018-05-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-018-04408-0

Internet

https://doi.org/10.1038/s41467-018-04408-0

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