Testosterone is an endogenous regulator of BAFF and splenic B cell number

Testosterone is an endogenous regulator of BAFF and splenic B cell number

Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Anna S. Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B. Buechler, Steve Lianoglou, Varun N. Kapoor, Maria E. Johansson, Johan B. Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T. Porse, Antonius G. Rolink, Hans Nissbrandt, Shannon J. Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C. I. Karlsson, Åsa Tivesten
Format: Artikel
Sprache:English
Veröffentlicht: Nature Portfolio 2018-05-01
Schriftenreihe:Nature Communications
Online Zugang:https://doi.org/10.1038/s41467-018-04408-0

Online

https://doi.org/10.1038/s41467-018-04408-0

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