Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1
Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epid...
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| Format: | Article |
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MDPI AG
2018-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/6/1654 |
| _version_ | 1811263525956354048 |
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| author | Akiko Hashimoto-Hachiya Gaku Tsuji Mika Murai Xianghong Yan Masutaka Furue |
| author_facet | Akiko Hashimoto-Hachiya Gaku Tsuji Mika Murai Xianghong Yan Masutaka Furue |
| author_sort | Akiko Hashimoto-Hachiya |
| collection | DOAJ |
| description | Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion. However, RCE-mediated IVL upregulation was AHR-dependent but OVOL1-independent. Coordinated upregulation of skin barrier proteins by RCE via AHR may be beneficial in the management of barrier-disrupted inflammatory skin diseases such as atopic dermatitis. |
| first_indexed | 2024-04-12T19:47:00Z |
| format | Article |
| id | doaj.art-d1f86c2dfb0e4e978adf889fa9f57fa5 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T19:47:00Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d1f86c2dfb0e4e978adf889fa9f57fa52022-12-22T03:18:57ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-06-01196165410.3390/ijms19061654ijms19061654Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1Akiko Hashimoto-Hachiya0Gaku Tsuji1Mika Murai2Xianghong Yan3Masutaka Furue4Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDepartment of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanP&G Innovation Godo Kaisha, Kobe 658-0032, JapanDepartment of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanRhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion. However, RCE-mediated IVL upregulation was AHR-dependent but OVOL1-independent. Coordinated upregulation of skin barrier proteins by RCE via AHR may be beneficial in the management of barrier-disrupted inflammatory skin diseases such as atopic dermatitis.http://www.mdpi.com/1422-0067/19/6/1654Rhodiola crenulata root extractaryl hydrocarbon receptorfilaggrinloricrininvolucrinOVOL1 |
| spellingShingle | Akiko Hashimoto-Hachiya Gaku Tsuji Mika Murai Xianghong Yan Masutaka Furue Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1 International Journal of Molecular Sciences Rhodiola crenulata root extract aryl hydrocarbon receptor filaggrin loricrin involucrin OVOL1 |
| title | Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1 |
| title_full | Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1 |
| title_fullStr | Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1 |
| title_full_unstemmed | Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1 |
| title_short | Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1 |
| title_sort | upregulation of flg lor and ivl expression by rhodiola crenulata root extract via aryl hydrocarbon receptor differential involvement of ovol1 |
| topic | Rhodiola crenulata root extract aryl hydrocarbon receptor filaggrin loricrin involucrin OVOL1 |
| url | http://www.mdpi.com/1422-0067/19/6/1654 |
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