Transcriptional Activation of <i>Chac1</i> and Other Atf4-Target Genes Induced by Extracellular <span style="font-variant: small-caps">l</span>-Serine Depletion is negated with Glycine Consumption in Hepa1-6 Hepatocarcinoma Cells

Transcriptional Activation of <i>Chac1</i> and Other Atf4-Target Genes Induced by Extracellular <span style="font-variant: small-caps">l</span>-Serine Depletion is negated with Glycine Consumption in Hepa1-6 Hepatocarcinoma Cells

Mouse embryonic fibroblasts lacking D-3-phosphoglycerate dehydrogenase (Phgdh), which catalyzes the first step of de novo synthesis of <span style="font-variant: small-caps;">l</span>-serine, are particularly sensitive to depletion of extracellular L-serine. In these cells, dep...

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Bibliographic Details
Main Authors: Momoko Hamano, Shozo Tomonaga, Yusuke Osaki, Hiroaki Oda, Hisanori Kato, Shigeki Furuya
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Nutrients
Subjects:
<span style="font-variant: small-caps">l</span>-serine deficiency
<i>Chac1</i>
Phgdh
Shmt
hepatoma
Online Access:https://www.mdpi.com/2072-6643/12/10/3018

Internet

https://www.mdpi.com/2072-6643/12/10/3018

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