Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease
Background/Aim. Infection is the major cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The aim of the study was to establish the most common bacterial agents of AE-COPD in patients hospitalized in a tertiary medical care institution. Methods. This retrospective study...
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| Format: | Article |
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Military Health Department, Ministry of Defance, Serbia
2017-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600176K.pdf |
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| author | Kolarov Violeta Zvezdin Biljana Đurić Mirna Hadnađev Mirjana Hromiš Sanja Nikoletić Katarina Trivić Bojana |
| author_facet | Kolarov Violeta Zvezdin Biljana Đurić Mirna Hadnađev Mirjana Hromiš Sanja Nikoletić Katarina Trivić Bojana |
| author_sort | Kolarov Violeta |
| collection | DOAJ |
| description | Background/Aim. Infection is the major cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The aim of the study was to establish the most common bacterial agents of AE-COPD in patients hospitalized in a tertiary medical care institution. Methods. This retrospective study included the patients hospitalized due to infective AE-COPD in the Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica in a 12-month period. We evaluated clinical data, spirometry, pathogen etiology in the patients with positive sputum findings and disease outcome. Results. The study included a total of 81 patients, 47 (58.02%) males and 34 (41.97%) females of the mean age of 65.7 years. The mean history of the disease was 14.5 years. The median forced expiratory volume in one second (FEV1) was 30.12%. The most common isolated pathogens was Pseudomonas aeruginosa (n = 36; 38.29%), followed by Haemophilus influenzae (n = 25; 26.59%) and Streptococcus pneumoniae (n = 16; 17.02%). Coinfections were present in 9 (9.57%) of the patients. The median FEV1 values of 28.67%, 37.23%, and 42.26% were registered in the patients with Pseudomonas aeruginosa, Haemophilus influenza, and Streptococcus pneumonia induced infection, respectively. The case fatality rate (CFR) was 6.2%. Of the deceased, 100% had Pseudomonas aeruginosa- induced infection. A statistically significant difference in FEV1 values was registered between the patients with and without Pseudomonas aeruginosa in their sputum finding (p = 0.016). Conclusion. The most common pathogens in patients with AE-COPD were Pseudomonas aeruginosa, Haemophilus influenzae, and Streptococcus pneumonia. The CFR was 6.2%. All (100%) deceased patients had the infection induced by Pseudomonas aeruginosa. |
| first_indexed | 2024-12-23T14:42:36Z |
| format | Article |
| id | doaj.art-d1fa30e8ffc140498e3be9954dfaa8b1 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-23T14:42:36Z |
| publishDate | 2017-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-d1fa30e8ffc140498e3be9954dfaa8b12022-12-21T17:43:10ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202017-01-0174322723110.2298/VSP141219176K0042-84501600176KMost common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary diseaseKolarov Violeta0Zvezdin Biljana1Đurić Mirna2Hadnađev Mirjana3Hromiš Sanja4Nikoletić Katarina5Trivić Bojana6Institute for Pulmonary Diseases of Vojvodina, Sremska KamenicaInstitute of Oncology of Vojvodina, Sremska Kamenica Institute of Oncology of Vojvodina, Sremska Kamenica Institute of Oncology of Vojvodina, Sremska Kamenica Institute of Oncology of Vojvodina, Sremska Kamenica Faculty of Medicine, Novi SadBoehringer Ingelheim Serbia, BelgradeBackground/Aim. Infection is the major cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The aim of the study was to establish the most common bacterial agents of AE-COPD in patients hospitalized in a tertiary medical care institution. Methods. This retrospective study included the patients hospitalized due to infective AE-COPD in the Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica in a 12-month period. We evaluated clinical data, spirometry, pathogen etiology in the patients with positive sputum findings and disease outcome. Results. The study included a total of 81 patients, 47 (58.02%) males and 34 (41.97%) females of the mean age of 65.7 years. The mean history of the disease was 14.5 years. The median forced expiratory volume in one second (FEV1) was 30.12%. The most common isolated pathogens was Pseudomonas aeruginosa (n = 36; 38.29%), followed by Haemophilus influenzae (n = 25; 26.59%) and Streptococcus pneumoniae (n = 16; 17.02%). Coinfections were present in 9 (9.57%) of the patients. The median FEV1 values of 28.67%, 37.23%, and 42.26% were registered in the patients with Pseudomonas aeruginosa, Haemophilus influenza, and Streptococcus pneumonia induced infection, respectively. The case fatality rate (CFR) was 6.2%. Of the deceased, 100% had Pseudomonas aeruginosa- induced infection. A statistically significant difference in FEV1 values was registered between the patients with and without Pseudomonas aeruginosa in their sputum finding (p = 0.016). Conclusion. The most common pathogens in patients with AE-COPD were Pseudomonas aeruginosa, Haemophilus influenzae, and Streptococcus pneumonia. The CFR was 6.2%. All (100%) deceased patients had the infection induced by Pseudomonas aeruginosa.http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600176K.pdfpulmonary disease, chronic obstructiveacute diseasediagnostic techniques and proceduressputumbacteriological techniquespseudomonas aeruginosahaemophilus influenzaestreptococcus pneumoniaemortality |
| spellingShingle | Kolarov Violeta Zvezdin Biljana Đurić Mirna Hadnađev Mirjana Hromiš Sanja Nikoletić Katarina Trivić Bojana Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease Vojnosanitetski Pregled pulmonary disease, chronic obstructive acute disease diagnostic techniques and procedures sputum bacteriological techniques pseudomonas aeruginosa haemophilus influenzae streptococcus pneumoniae mortality |
| title | Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease |
| title_full | Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease |
| title_fullStr | Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease |
| title_full_unstemmed | Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease |
| title_short | Most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease |
| title_sort | most common bacterial agents in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease |
| topic | pulmonary disease, chronic obstructive acute disease diagnostic techniques and procedures sputum bacteriological techniques pseudomonas aeruginosa haemophilus influenzae streptococcus pneumoniae mortality |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600176K.pdf |
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