Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem
The review summarizes information on possibilities of plant preparations use for collagen structure and metabolism disturbances correction. Biologically active compounds of plant origin can both stimulate and inhibit the biosynthesis of various types collagens, accelerate or slower down their catabo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Igor Sikorsky Kyiv Polytechnic Institute
2023-04-01
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| Series: | Innovative Biosystems and Bioengineering |
| Subjects: | |
| Online Access: | http://ibb.kpi.ua/article/view/275743 |
| _version_ | 1827382925323141120 |
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| author | Larysa Bondarenko Maria Kalachinskaya Natalia Serhiichuk Valentyna Motronenko Oksana Biloshytska |
| author_facet | Larysa Bondarenko Maria Kalachinskaya Natalia Serhiichuk Valentyna Motronenko Oksana Biloshytska |
| author_sort | Larysa Bondarenko |
| collection | DOAJ |
| description | The review summarizes information on possibilities of plant preparations use for collagen structure and metabolism disturbances correction. Biologically active compounds of plant origin can both stimulate and inhibit the biosynthesis of various types collagens, accelerate or slower down their catabolism, regulate the activity of enzymes involved in the collagen's metabolism. Most of the studied compounds realize their effects simultaneously by several mechanisms. Among them, the most common are the direct influence of the substance on the processes of collagen genes expression and indirect influence via TGF-beta1- pathway. In addition, a fairly common are effects on collagen synthesis by changing organism's pools of free amino acids (as the starting compounds for this protein synthesis) and by regulation of hydroxylases (performing collagen post-translational modifications and crosslinking). Besides TGF-beta1 others cytokines can also be involved in the processes of collagen metabolism regulation by compounds of plant origin. In particular, this is characteristic of triterpenes and phytoestrogens. Such a variety of methods for collagens metabolism regulation creates a wide range of possibilities for developing new preparations based on extracts or pure plant compounds able to correct connective tissue collagen structure and metabolic disorders with minimal adverse effects. Fundamentally different possibilities for the influence of plant organisms on collagens are opened with the use of genetically modified plants. Recombinant collagens allow to obtain proteins with new programmed features, making it possible to synthesize proteins with predetermined properties for medical use. |
| first_indexed | 2024-03-08T14:30:29Z |
| format | Article |
| id | doaj.art-d1fa46c77ffe457c8c870a03235cbf08 |
| institution | Directory Open Access Journal |
| issn | 2616-177X |
| language | English |
| last_indexed | 2024-03-08T14:30:29Z |
| publishDate | 2023-04-01 |
| publisher | Igor Sikorsky Kyiv Polytechnic Institute |
| record_format | Article |
| series | Innovative Biosystems and Bioengineering |
| spelling | doaj.art-d1fa46c77ffe457c8c870a03235cbf082024-01-12T12:17:16ZengIgor Sikorsky Kyiv Polytechnic InstituteInnovative Biosystems and Bioengineering2616-177X2023-04-017131310.20535/ibb.2023.7.1.275743313908Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of ProblemLarysa Bondarenko0https://orcid.org/0000-0001-5107-8148Maria Kalachinskaya1https://orcid.org/0000-0002-6940-2249Natalia Serhiichuk2https://orcid.org/0000-0001-6690-0114Valentyna Motronenko3https://orcid.org/0000-0002-6122-4513Oksana Biloshytska4https://orcid.org/0000-0002-2901-9667SI "Institute of Pharmacology & Toxicology of the National Academy of Medical Sciences of Ukraine"Open International University of Human Development "Ukraine"Open International University of Human Development "Ukraine"Igor Sikorsky Kyiv Polytechnic InstituteIgor Sikorsky Kyiv Polytechnic InstituteThe review summarizes information on possibilities of plant preparations use for collagen structure and metabolism disturbances correction. Biologically active compounds of plant origin can both stimulate and inhibit the biosynthesis of various types collagens, accelerate or slower down their catabolism, regulate the activity of enzymes involved in the collagen's metabolism. Most of the studied compounds realize their effects simultaneously by several mechanisms. Among them, the most common are the direct influence of the substance on the processes of collagen genes expression and indirect influence via TGF-beta1- pathway. In addition, a fairly common are effects on collagen synthesis by changing organism's pools of free amino acids (as the starting compounds for this protein synthesis) and by regulation of hydroxylases (performing collagen post-translational modifications and crosslinking). Besides TGF-beta1 others cytokines can also be involved in the processes of collagen metabolism regulation by compounds of plant origin. In particular, this is characteristic of triterpenes and phytoestrogens. Such a variety of methods for collagens metabolism regulation creates a wide range of possibilities for developing new preparations based on extracts or pure plant compounds able to correct connective tissue collagen structure and metabolic disorders with minimal adverse effects. Fundamentally different possibilities for the influence of plant organisms on collagens are opened with the use of genetically modified plants. Recombinant collagens allow to obtain proteins with new programmed features, making it possible to synthesize proteins with predetermined properties for medical use.http://ibb.kpi.ua/article/view/275743plant preparationscollagen structurecollagen metabolismdisturbances correctionrecombinant collagens |
| spellingShingle | Larysa Bondarenko Maria Kalachinskaya Natalia Serhiichuk Valentyna Motronenko Oksana Biloshytska Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem Innovative Biosystems and Bioengineering plant preparations collagen structure collagen metabolism disturbances correction recombinant collagens |
| title | Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem |
| title_full | Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem |
| title_fullStr | Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem |
| title_full_unstemmed | Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem |
| title_short | Possibilities of Plant Preparations Use for Collagen Structure and Metabolism Disturbances Correction: Modern State of Problem |
| title_sort | possibilities of plant preparations use for collagen structure and metabolism disturbances correction modern state of problem |
| topic | plant preparations collagen structure collagen metabolism disturbances correction recombinant collagens |
| url | http://ibb.kpi.ua/article/view/275743 |
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