Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal study
ObjectCognitive decline and obesity are major global public health issues, and their association has been widely acknowledged. The link between the visceral adiposity index (VAI) and cognitive function in the Chinese population remains uncertain. This study aims to investigate the effects of VAI lev...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1270239/full |
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| author | Zhaohao Zeng Zhaohao Zeng Zhaohao Zeng Kunyu Huang Yanmei Cen Wen Jin Yingao Shen Lijiao Xiong Lijiao Xiong Lijiao Xiong Fengju Mao Fengju Mao Guo Hong Guo Hong Guo Hong Yu Luo Yu Luo Yu Luo Xiaoguang Luo Xiaoguang Luo |
| author_facet | Zhaohao Zeng Zhaohao Zeng Zhaohao Zeng Kunyu Huang Yanmei Cen Wen Jin Yingao Shen Lijiao Xiong Lijiao Xiong Lijiao Xiong Fengju Mao Fengju Mao Guo Hong Guo Hong Guo Hong Yu Luo Yu Luo Yu Luo Xiaoguang Luo Xiaoguang Luo |
| author_sort | Zhaohao Zeng |
| collection | DOAJ |
| description | ObjectCognitive decline and obesity are major global public health issues, and their association has been widely acknowledged. The link between the visceral adiposity index (VAI) and cognitive function in the Chinese population remains uncertain. This study aims to investigate the effects of VAI levels on cognitive function in the Chinese middle-aged and elderly population.MethodsWe analyzed longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) collected in 2011, 2013, 2015, and 2018. VAI levels were divided into three tertiles. Generalized estimating equation (GEE) models were used to explore the relationships between VAI levels and cognitive function, including overall cognitive scores, episodic memory, and mental status. Adjustments were made for potential confounders.ResultsThe study consisted of 2,677 participants. Contrary to expectations, higher VAI levels were associated with higher overall cognitive scores and improved episodic memory scores, while no significant effect was observed on mental status. The GEE models consistently indicated that higher VAI levels were associated with higher overall cognitive scores, primarily due to their association with episodic memory. Stratified analyses revealed that the VAI was associated with better cognitive function primarily in males, individuals under 60 years old, those with lower education levels, rural residents, and married individuals, mainly in relation to episodic memory. No significant interactions were observed between VAI and demographic factors.ConclusionOur findings suggest that higher visceral adiposity is associated with slower cognitive decline in the Chinese middle-aged and elderly population, especially in its association with episodic memory. These results underline the need to further investigate the potential protective role of visceral fat in cognitive function, potentially offering new insights for interventions to enhance cognitive function and prevent dementia in this population. |
| first_indexed | 2024-03-11T17:10:46Z |
| format | Article |
| id | doaj.art-d1fb29cc3eef42f69007896fe9078afc |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T17:10:46Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d1fb29cc3eef42f69007896fe9078afc2023-10-20T06:36:37ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-10-011510.3389/fnagi.2023.12702391270239Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal studyZhaohao Zeng0Zhaohao Zeng1Zhaohao Zeng2Kunyu Huang3Yanmei Cen4Wen Jin5Yingao Shen6Lijiao Xiong7Lijiao Xiong8Lijiao Xiong9Fengju Mao10Fengju Mao11Guo Hong12Guo Hong13Guo Hong14Yu Luo15Yu Luo16Yu Luo17Xiaoguang Luo18Xiaoguang Luo19Department of Neurology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaThe First Clinical Medical College of Jinan University, Guangzhou, Guangdong, ChinaGuangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Pharmacy, Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University, Shanwei, Guangdong, ChinaThe First Clinical Medical College of Jinan University, Guangzhou, Guangdong, ChinaDepartment of Neurology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaDepartment of Neurology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaThe First Clinical Medical College of Jinan University, Guangzhou, Guangdong, ChinaGuangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Geriatrics, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaDepartment of Neurology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaGuangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaThe First Clinical Medical College of Jinan University, Guangzhou, Guangdong, ChinaGuangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaThe First Clinical Medical College of Jinan University, Guangzhou, Guangdong, ChinaGuangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, ChinaGuangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, ChinaObjectCognitive decline and obesity are major global public health issues, and their association has been widely acknowledged. The link between the visceral adiposity index (VAI) and cognitive function in the Chinese population remains uncertain. This study aims to investigate the effects of VAI levels on cognitive function in the Chinese middle-aged and elderly population.MethodsWe analyzed longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) collected in 2011, 2013, 2015, and 2018. VAI levels were divided into three tertiles. Generalized estimating equation (GEE) models were used to explore the relationships between VAI levels and cognitive function, including overall cognitive scores, episodic memory, and mental status. Adjustments were made for potential confounders.ResultsThe study consisted of 2,677 participants. Contrary to expectations, higher VAI levels were associated with higher overall cognitive scores and improved episodic memory scores, while no significant effect was observed on mental status. The GEE models consistently indicated that higher VAI levels were associated with higher overall cognitive scores, primarily due to their association with episodic memory. Stratified analyses revealed that the VAI was associated with better cognitive function primarily in males, individuals under 60 years old, those with lower education levels, rural residents, and married individuals, mainly in relation to episodic memory. No significant interactions were observed between VAI and demographic factors.ConclusionOur findings suggest that higher visceral adiposity is associated with slower cognitive decline in the Chinese middle-aged and elderly population, especially in its association with episodic memory. These results underline the need to further investigate the potential protective role of visceral fat in cognitive function, potentially offering new insights for interventions to enhance cognitive function and prevent dementia in this population.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1270239/fullcognitive functionvisceral adiposity indexvisceral obesityChina health and retirement longitudinal studydementia |
| spellingShingle | Zhaohao Zeng Zhaohao Zeng Zhaohao Zeng Kunyu Huang Yanmei Cen Wen Jin Yingao Shen Lijiao Xiong Lijiao Xiong Lijiao Xiong Fengju Mao Fengju Mao Guo Hong Guo Hong Guo Hong Yu Luo Yu Luo Yu Luo Xiaoguang Luo Xiaoguang Luo Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal study Frontiers in Aging Neuroscience cognitive function visceral adiposity index visceral obesity China health and retirement longitudinal study dementia |
| title | Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal study |
| title_full | Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal study |
| title_fullStr | Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal study |
| title_full_unstemmed | Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal study |
| title_short | Elevated visceral adiposity index linked to improved cognitive function in middle-aged and elderly Chinese: evidence from the China health and retirement longitudinal study |
| title_sort | elevated visceral adiposity index linked to improved cognitive function in middle aged and elderly chinese evidence from the china health and retirement longitudinal study |
| topic | cognitive function visceral adiposity index visceral obesity China health and retirement longitudinal study dementia |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1270239/full |
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