Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice
The effects of Helicobacter pylori (Hp)-related chronic gastritis on gastrointestinal microorganisms or brain neurotransmitters are not fully understood. Here, this study selected SPF C57BL/6 mice to set up a Hp-related chronic gastritis experiment group and a blank control group, and used omics to...
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| Format: | Article |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1472437/full |
| _version_ | 1826948258953428992 |
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| author | Hai-Hua Liu Tang-Tang Lin Qi-Jia Zhang Ling Zhang Jin-Ying Fang Ling Hu |
| author_facet | Hai-Hua Liu Tang-Tang Lin Qi-Jia Zhang Ling Zhang Jin-Ying Fang Ling Hu |
| author_sort | Hai-Hua Liu |
| collection | DOAJ |
| description | The effects of Helicobacter pylori (Hp)-related chronic gastritis on gastrointestinal microorganisms or brain neurotransmitters are not fully understood. Here, this study selected SPF C57BL/6 mice to set up a Hp-related chronic gastritis experiment group and a blank control group, and used omics to explore the specific effects of Hp-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice. The Tyramine (TyrA) content in the female experiment group’s brain was considerably reduced compared to the female control group (p < 0.01), and TyrA was strongly correlated with 13 gastrointestinal microorganisms with significant differences, such as Acinetobacter_baumannii (p < 0.05). The His content in the male experiment group’s brain was significantly higher than that in the male control group (p < 0.05), and His was strongly correlated with four gastrointestinal microorganisms with significant differences, such as Acinetobacter_baumannii (p < 0.05). The Levodopa (DOPA) content in the female control group’s brain was significantly lower than that in the male control group (p < 0.05), and DOPA was strongly correlated with 19 gastrointestinal microorganisms with significant differences, such as Achromobacter_xylosoxidans (p < 0.05). The contents of L-Glutamine (Gln), L-Glutamine (GABA), Noradrenaline hydrochloride (NE), and Adrenaline hydrochloride (E) in the female experiment group’s brain were significantly lower than those in the male experiment group (p < 0.05), and Gln, GABA, NE, and E were strongly correlated with 41, 28, 40, and 33 gastrointestinal microorganisms with significant differences (p < 0.05), respectively. These results indicate that Hp-related chronic gastritis could affect gastrointestinal microorganisms and brain neurotransmitters in mice with certain gender differences, and the changes in brain neurotransmitters might be related to the changes in gastrointestinal microorganisms. |
| first_indexed | 2025-02-17T21:47:07Z |
| format | Article |
| id | doaj.art-d1fd6d062ca548c8b181e77b51a5d07f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2025-02-17T21:47:07Z |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-d1fd6d062ca548c8b181e77b51a5d07f2024-12-06T04:32:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.14724371472437Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in miceHai-Hua Liu0Tang-Tang Lin1Qi-Jia Zhang2Ling Zhang3Jin-Ying Fang4Ling Hu5First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaFirst Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaInstitute of Gastroenterology, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Affiliated Hospital of Zunyi Medical University, Zunyi Medical University, Zunyi, ChinaFirst Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaInstitute of Gastroenterology, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe effects of Helicobacter pylori (Hp)-related chronic gastritis on gastrointestinal microorganisms or brain neurotransmitters are not fully understood. Here, this study selected SPF C57BL/6 mice to set up a Hp-related chronic gastritis experiment group and a blank control group, and used omics to explore the specific effects of Hp-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice. The Tyramine (TyrA) content in the female experiment group’s brain was considerably reduced compared to the female control group (p < 0.01), and TyrA was strongly correlated with 13 gastrointestinal microorganisms with significant differences, such as Acinetobacter_baumannii (p < 0.05). The His content in the male experiment group’s brain was significantly higher than that in the male control group (p < 0.05), and His was strongly correlated with four gastrointestinal microorganisms with significant differences, such as Acinetobacter_baumannii (p < 0.05). The Levodopa (DOPA) content in the female control group’s brain was significantly lower than that in the male control group (p < 0.05), and DOPA was strongly correlated with 19 gastrointestinal microorganisms with significant differences, such as Achromobacter_xylosoxidans (p < 0.05). The contents of L-Glutamine (Gln), L-Glutamine (GABA), Noradrenaline hydrochloride (NE), and Adrenaline hydrochloride (E) in the female experiment group’s brain were significantly lower than those in the male experiment group (p < 0.05), and Gln, GABA, NE, and E were strongly correlated with 41, 28, 40, and 33 gastrointestinal microorganisms with significant differences (p < 0.05), respectively. These results indicate that Hp-related chronic gastritis could affect gastrointestinal microorganisms and brain neurotransmitters in mice with certain gender differences, and the changes in brain neurotransmitters might be related to the changes in gastrointestinal microorganisms.https://www.frontiersin.org/articles/10.3389/fphar.2024.1472437/fullHp-related chronic gastritismicroorganismneurotransmittermetagenomicsmetabolomics |
| spellingShingle | Hai-Hua Liu Tang-Tang Lin Qi-Jia Zhang Ling Zhang Jin-Ying Fang Ling Hu Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice Frontiers in Pharmacology Hp-related chronic gastritis microorganism neurotransmitter metagenomics metabolomics |
| title | Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice |
| title_full | Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice |
| title_fullStr | Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice |
| title_full_unstemmed | Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice |
| title_short | Effect of Helicobacter pylori-related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice |
| title_sort | effect of helicobacter pylori related chronic gastritis on gastrointestinal microorganisms and brain neurotransmitters in mice |
| topic | Hp-related chronic gastritis microorganism neurotransmitter metagenomics metabolomics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1472437/full |
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