The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze
Background & Aims: Memory and its role in learning have long been of interest to humans. Therefore, human beings have always sought ways to enhance their memory and reduce its deficit. In the present study, the effect of pumpkin seed extract on memory and learning in adult male rats were studied...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2014-01-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_16147_04185f619f31f97f976266cd54f1a239.pdf |
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| author | Zahra Tamadonfard Leili Sepehrara Habibalah Jouhary |
| author_facet | Zahra Tamadonfard Leili Sepehrara Habibalah Jouhary |
| author_sort | Zahra Tamadonfard |
| collection | DOAJ |
| description | Background & Aims: Memory and its role in learning have long been of interest to humans. Therefore, human beings have always sought ways to enhance their memory and reduce its deficit. In the present study, the effect of pumpkin seed extract on memory and learning in adult male rats were studied. Methods: The rats (weighing 180-220 g) were divided into 7 groups (n = 8); control, sham (control and sham groups had normal food and water, but a week before the test, the control group received distilled water through oral gavage), and experimental groups. The experimental groups received pumpkin seed extract in doses of 100, 200, 400, and 800 mg/kg of body weight daily for 17 days. Training began 12 days after receiving seed extract. The extract was also administered during training. On day 18, probe trial was performed without the administration of the extract. Results: Results showed that, in the groups receiving the extract, spatial memory increased significantly (P < 0.05); thisincrease, compared to the control and sham groups, was dose dependent. Conclusion: The results indicate that administration of pumpkin seed extract, due to its content of omega fatty acids (oleic acid, linoleic acid) and vitamins D and E, increases spatial memory and learning |
| first_indexed | 2024-03-13T02:08:32Z |
| format | Article |
| id | doaj.art-d200a45ae287435488d9bf3aad807acb |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:08:32Z |
| publishDate | 2014-01-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-d200a45ae287435488d9bf3aad807acb2023-07-01T05:25:56ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432014-01-0121655156116147The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes mazeZahra Tamadonfard0Leili Sepehrara1Habibalah Jouhary2Department of Animal Biology, Islamic Azad University, Jahrom Branch,Jahrom, IranAssistant Professor, Department of Biology, Islamic Azad University, Kazerun Branch, Kazerun, IranAssistant Professor, Department ofBiology, Islamic Azad University, Darab Branch, Darab, IranBackground & Aims: Memory and its role in learning have long been of interest to humans. Therefore, human beings have always sought ways to enhance their memory and reduce its deficit. In the present study, the effect of pumpkin seed extract on memory and learning in adult male rats were studied. Methods: The rats (weighing 180-220 g) were divided into 7 groups (n = 8); control, sham (control and sham groups had normal food and water, but a week before the test, the control group received distilled water through oral gavage), and experimental groups. The experimental groups received pumpkin seed extract in doses of 100, 200, 400, and 800 mg/kg of body weight daily for 17 days. Training began 12 days after receiving seed extract. The extract was also administered during training. On day 18, probe trial was performed without the administration of the extract. Results: Results showed that, in the groups receiving the extract, spatial memory increased significantly (P < 0.05); thisincrease, compared to the control and sham groups, was dose dependent. Conclusion: The results indicate that administration of pumpkin seed extract, due to its content of omega fatty acids (oleic acid, linoleic acid) and vitamins D and E, increases spatial memory and learninghttps://jkmu.kmu.ac.ir/article_16147_04185f619f31f97f976266cd54f1a239.pdfbarnes mazespatial memorylearningoleic acidlinoleic acid |
| spellingShingle | Zahra Tamadonfard Leili Sepehrara Habibalah Jouhary The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze Journal of Kerman University of Medical Sciences barnes maze spatial memory learning oleic acid linoleic acid |
| title | The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze |
| title_full | The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze |
| title_fullStr | The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze |
| title_full_unstemmed | The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze |
| title_short | The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze |
| title_sort | effect of pumpkin seed extract on the spatial learning and memory of adult male ratsin barnes maze |
| topic | barnes maze spatial memory learning oleic acid linoleic acid |
| url | https://jkmu.kmu.ac.ir/article_16147_04185f619f31f97f976266cd54f1a239.pdf |
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