Sociodemographic disparities in corticolimbic structures.
This study sought to examine the interactive relations of socioeconomic status and race to corticolimbic regions that may play a key role in translating stress to the poor health outcomes overrepresented among those of lower socioeconomic status and African American race. Participants were 200 commu...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0216338 |
| _version_ | 1819006899959365632 |
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| author | Danielle Shaked Zachary B Millman Danielle L Beatty Moody William F Rosenberger Hui Shao Leslie I Katzel Christos Davatzikos Rao P Gullapalli Stephen L Seliger Guray Erus Michele K Evans Alan B Zonderman Shari R Waldstein |
| author_facet | Danielle Shaked Zachary B Millman Danielle L Beatty Moody William F Rosenberger Hui Shao Leslie I Katzel Christos Davatzikos Rao P Gullapalli Stephen L Seliger Guray Erus Michele K Evans Alan B Zonderman Shari R Waldstein |
| author_sort | Danielle Shaked |
| collection | DOAJ |
| description | This study sought to examine the interactive relations of socioeconomic status and race to corticolimbic regions that may play a key role in translating stress to the poor health outcomes overrepresented among those of lower socioeconomic status and African American race. Participants were 200 community-dwelling, self-identified African American and White adults from the Healthy Aging in Neighborhoods of Diversity across the Life Span SCAN study. Brain volumes were derived using T1-weighted MP-RAGE images. Socioeconomic status by race interactions were observed for right medial prefrontal cortex (B = .26, p = .014), left medial prefrontal cortex (B = .26, p = .017), left orbital prefrontal cortex (B = .22, p = .037), and left anterior cingulate cortex (B = .27, p = .018), wherein higher socioeconomic status Whites had greater volumes than all other groups. Additionally, higher versus lower socioeconomic status persons had greater right and left hippocampal (B = -.15, p = .030; B = -.19, p = .004, respectively) and amygdalar (B = -.17, p = .015; B = -.21; p = .002, respectively) volumes. Whites had greater right and left hippocampal (B = -.17, p = .012; B = -.20, p = .003, respectively), right orbital prefrontal cortex (B = -.34, p < 0.001), and right anterior cingulate cortex (B = -.18, p = 0.011) volumes than African Americans. Among many factors, the higher levels of lifetime chronic stress associated with lower socioeconomic status and African American race may adversely affect corticolimbic circuitry. These relations may help explain race- and socioeconomic status-related disparities in adverse health outcomes. |
| first_indexed | 2024-12-21T00:16:01Z |
| format | Article |
| id | doaj.art-d20156142cb749b7b9112c17518b6c14 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T00:16:01Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d20156142cb749b7b9112c17518b6c142022-12-21T19:22:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01145e021633810.1371/journal.pone.0216338Sociodemographic disparities in corticolimbic structures.Danielle ShakedZachary B MillmanDanielle L Beatty MoodyWilliam F RosenbergerHui ShaoLeslie I KatzelChristos DavatzikosRao P GullapalliStephen L SeligerGuray ErusMichele K EvansAlan B ZondermanShari R WaldsteinThis study sought to examine the interactive relations of socioeconomic status and race to corticolimbic regions that may play a key role in translating stress to the poor health outcomes overrepresented among those of lower socioeconomic status and African American race. Participants were 200 community-dwelling, self-identified African American and White adults from the Healthy Aging in Neighborhoods of Diversity across the Life Span SCAN study. Brain volumes were derived using T1-weighted MP-RAGE images. Socioeconomic status by race interactions were observed for right medial prefrontal cortex (B = .26, p = .014), left medial prefrontal cortex (B = .26, p = .017), left orbital prefrontal cortex (B = .22, p = .037), and left anterior cingulate cortex (B = .27, p = .018), wherein higher socioeconomic status Whites had greater volumes than all other groups. Additionally, higher versus lower socioeconomic status persons had greater right and left hippocampal (B = -.15, p = .030; B = -.19, p = .004, respectively) and amygdalar (B = -.17, p = .015; B = -.21; p = .002, respectively) volumes. Whites had greater right and left hippocampal (B = -.17, p = .012; B = -.20, p = .003, respectively), right orbital prefrontal cortex (B = -.34, p < 0.001), and right anterior cingulate cortex (B = -.18, p = 0.011) volumes than African Americans. Among many factors, the higher levels of lifetime chronic stress associated with lower socioeconomic status and African American race may adversely affect corticolimbic circuitry. These relations may help explain race- and socioeconomic status-related disparities in adverse health outcomes.https://doi.org/10.1371/journal.pone.0216338 |
| spellingShingle | Danielle Shaked Zachary B Millman Danielle L Beatty Moody William F Rosenberger Hui Shao Leslie I Katzel Christos Davatzikos Rao P Gullapalli Stephen L Seliger Guray Erus Michele K Evans Alan B Zonderman Shari R Waldstein Sociodemographic disparities in corticolimbic structures. PLoS ONE |
| title | Sociodemographic disparities in corticolimbic structures. |
| title_full | Sociodemographic disparities in corticolimbic structures. |
| title_fullStr | Sociodemographic disparities in corticolimbic structures. |
| title_full_unstemmed | Sociodemographic disparities in corticolimbic structures. |
| title_short | Sociodemographic disparities in corticolimbic structures. |
| title_sort | sociodemographic disparities in corticolimbic structures |
| url | https://doi.org/10.1371/journal.pone.0216338 |
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