The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes
There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and endogenous origin, have been shown to play a role in diabetes...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1766 |
| _version_ | 1797487200691027968 |
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| author | Matthew Snelson Elisa Lucut Melinda T. Coughlan |
| author_facet | Matthew Snelson Elisa Lucut Melinda T. Coughlan |
| author_sort | Matthew Snelson |
| collection | DOAJ |
| description | There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and endogenous origin, have been shown to play a role in diabetes pathophysiology, in part by their ligation to the receptor for advanced glycation endproducts (RAGE), leading to a proinflammatory signalling cascade. RAGE signalling has been demonstrated to play a role in the development of intestinal inflammation and permeability in Crohn’s disease and ulcerative colitis. In this review, we explore the role of AGE-RAGE signalling and intestinal permeability and explore whether activation of RAGE on the intestinal epithelium may be a downstream event contributing to the pathogenesis of diabetes complications. |
| first_indexed | 2024-03-09T23:45:11Z |
| format | Article |
| id | doaj.art-d2018a3162d24fc3be00d55289b3f8ce |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:45:11Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d2018a3162d24fc3be00d55289b3f8ce2023-11-23T16:46:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01233176610.3390/ijms23031766The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in DiabetesMatthew Snelson0Elisa Lucut1Melinda T. Coughlan2Department of Diabetes, Central Clinical School, Monash University Melbourne, Melbourne, VIC 3004, AustraliaDepartment of Diabetes, Central Clinical School, Monash University Melbourne, Melbourne, VIC 3004, AustraliaDepartment of Diabetes, Central Clinical School, Monash University Melbourne, Melbourne, VIC 3004, AustraliaThere is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and endogenous origin, have been shown to play a role in diabetes pathophysiology, in part by their ligation to the receptor for advanced glycation endproducts (RAGE), leading to a proinflammatory signalling cascade. RAGE signalling has been demonstrated to play a role in the development of intestinal inflammation and permeability in Crohn’s disease and ulcerative colitis. In this review, we explore the role of AGE-RAGE signalling and intestinal permeability and explore whether activation of RAGE on the intestinal epithelium may be a downstream event contributing to the pathogenesis of diabetes complications.https://www.mdpi.com/1422-0067/23/3/1766advanced glycation endproductsreceptor for advanced glycation endproductsdiabetesintestinal permeability |
| spellingShingle | Matthew Snelson Elisa Lucut Melinda T. Coughlan The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes International Journal of Molecular Sciences advanced glycation endproducts receptor for advanced glycation endproducts diabetes intestinal permeability |
| title | The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes |
| title_full | The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes |
| title_fullStr | The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes |
| title_full_unstemmed | The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes |
| title_short | The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes |
| title_sort | role of age rage signalling as a modulator of gut permeability in diabetes |
| topic | advanced glycation endproducts receptor for advanced glycation endproducts diabetes intestinal permeability |
| url | https://www.mdpi.com/1422-0067/23/3/1766 |
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