The effect of fenugreek on nociceptive response in diabetic rats
Abstract Introduction: Diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. This study was designed to investigate the effect of Trigonella foenum-graecum (TFG) on formalin-induced nocice...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2009-01-01
|
| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-5&slc_lang=en&sid=1 |
| _version_ | 1797281020066660352 |
|---|---|
| author | Mehrdad Roghani Mohammad Reza Vaez Mahdavi Mohsen Khalili Seyed Rohollah Miri |
| author_facet | Mehrdad Roghani Mohammad Reza Vaez Mahdavi Mohsen Khalili Seyed Rohollah Miri |
| author_sort | Mehrdad Roghani |
| collection | DOAJ |
| description | Abstract Introduction: Diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. This study was designed to investigate the effect of Trigonella foenum-graecum (TFG) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (STZ)-induced diabetic rats. Methods: For this purpose, STZ-diabetic rats received intraperitoneal injection of aqueous leaf extract of TFG (200 mg/kg every other day for a period of one month). Results: It was found out that TFG treatment did cause a significant reduction in blood glucose in diabetic rats and TFG-treated diabetic rats exhibited a lower nociceptive score as compared to untreated-diabetic ones. Meanwhile, TFG treatment reduced the nociceptive score in both phases of the formalin test. In contrast, sodium salicylate as positive control only reduced this score in the second phase of the test. Discussion: The results suggest therapeutic potential of aqueous extract of fenugreek for treating painful diabetic neuropathy. |
| first_indexed | 2024-03-07T16:49:32Z |
| format | Article |
| id | doaj.art-d2021e49598648cb9ee6047d785ba353 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:49:32Z |
| publishDate | 2009-01-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-d2021e49598648cb9ee6047d785ba3532024-03-03T05:36:31ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422009-01-01112225The effect of fenugreek on nociceptive response in diabetic ratsMehrdad RoghaniMohammad Reza Vaez MahdaviMohsen KhaliliSeyed Rohollah MiriAbstract Introduction: Diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. This study was designed to investigate the effect of Trigonella foenum-graecum (TFG) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (STZ)-induced diabetic rats. Methods: For this purpose, STZ-diabetic rats received intraperitoneal injection of aqueous leaf extract of TFG (200 mg/kg every other day for a period of one month). Results: It was found out that TFG treatment did cause a significant reduction in blood glucose in diabetic rats and TFG-treated diabetic rats exhibited a lower nociceptive score as compared to untreated-diabetic ones. Meanwhile, TFG treatment reduced the nociceptive score in both phases of the formalin test. In contrast, sodium salicylate as positive control only reduced this score in the second phase of the test. Discussion: The results suggest therapeutic potential of aqueous extract of fenugreek for treating painful diabetic neuropathy.http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-5&slc_lang=en&sid=1Trigonella foenum-graecumDiabetes mellitusPainRat |
| spellingShingle | Mehrdad Roghani Mohammad Reza Vaez Mahdavi Mohsen Khalili Seyed Rohollah Miri The effect of fenugreek on nociceptive response in diabetic rats Basic and Clinical Neuroscience Trigonella foenum-graecum Diabetes mellitus Pain Rat |
| title | The effect of fenugreek on nociceptive response in diabetic rats |
| title_full | The effect of fenugreek on nociceptive response in diabetic rats |
| title_fullStr | The effect of fenugreek on nociceptive response in diabetic rats |
| title_full_unstemmed | The effect of fenugreek on nociceptive response in diabetic rats |
| title_short | The effect of fenugreek on nociceptive response in diabetic rats |
| title_sort | effect of fenugreek on nociceptive response in diabetic rats |
| topic | Trigonella foenum-graecum Diabetes mellitus Pain Rat |
| url | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-5&slc_lang=en&sid=1 |
| work_keys_str_mv | AT mehrdadroghani theeffectoffenugreekonnociceptiveresponseindiabeticrats AT mohammadrezavaezmahdavi theeffectoffenugreekonnociceptiveresponseindiabeticrats AT mohsenkhalili theeffectoffenugreekonnociceptiveresponseindiabeticrats AT seyedrohollahmiri theeffectoffenugreekonnociceptiveresponseindiabeticrats AT mehrdadroghani effectoffenugreekonnociceptiveresponseindiabeticrats AT mohammadrezavaezmahdavi effectoffenugreekonnociceptiveresponseindiabeticrats AT mohsenkhalili effectoffenugreekonnociceptiveresponseindiabeticrats AT seyedrohollahmiri effectoffenugreekonnociceptiveresponseindiabeticrats |