The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum

ABSTRACT The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum. PfCRT resides at the digestive vacuole of the parasite, where hemoglobin taken up by the parasite from its host cell is degraded. P...

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Bibliographic Details
Main Authors: Cecilia P. Sanchez, Erin D. T. Manson, Sonia Moliner Cubel, Luis Mandel, Stefan K. Weidt, Michael P. Barrett, Michael Lanzer
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
PfCRT
oligopeptides
metabolomics
malaria
P. falciparum
membrane transport
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01101-22

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