Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Abstract The non-isothermal method for prediction of chemical stability of pharmaceuticals has been discussed in the literature for almost half a century but it has not yet been systematically evaluated. The purpose of this study was to carry out a comprehensive experimental evaluation of the non-is...

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Bibliographic Details
Main Authors:	Agnes Kairer, Shaoxin Feng, Valentino J. Stella, Thomas K. Karami
Format:	Article
Language:	English
Published:	SpringerOpen 2017-04-01
Series:	AAPS Open
Subjects:	Non-isothermal Chemical stability Degradation kinetics Arrhenius theory Simulations Linear regressions
Online Access:	http://link.springer.com/article/10.1186/s41120-017-0012-y

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