Septin Remodeling During Mammalian Cytokinesis
Cytokinesis mediates the final separation of a mother cell into two daughter cells. Septins are recruited to the cleavage furrow at an early stage. During cytokinetic progression the septin cytoskeleton is constantly rearranged, ultimately leading to a concentration of septins within the intercellul...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-11-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.768309/full |
| _version_ | 1831592208758734848 |
|---|---|
| author | Giulia Russo Michael Krauss |
| author_facet | Giulia Russo Michael Krauss |
| author_sort | Giulia Russo |
| collection | DOAJ |
| description | Cytokinesis mediates the final separation of a mother cell into two daughter cells. Septins are recruited to the cleavage furrow at an early stage. During cytokinetic progression the septin cytoskeleton is constantly rearranged, ultimately leading to a concentration of septins within the intercellular bridge (ICB), and to the formation of two rings adjacent to the midbody that aid ESCRT-dependent abscission. The molecular mechanisms underlying this behavior are poorly understood. Based on observations that septins can associate with actin, microtubules and associated motors, we review here established roles of septins in mammalian cytokinesis, and discuss, how septins may support cytokinetic progression by exerting their functions at particular sites. Finally, we discuss how this might be assisted by phosphoinositide-metabolizing enzymes. |
| first_indexed | 2024-12-18T01:39:26Z |
| format | Article |
| id | doaj.art-d20826a91b2e4dea932682d947d475f8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-18T01:39:26Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d20826a91b2e4dea932682d947d475f82022-12-21T21:25:23ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-11-01910.3389/fcell.2021.768309768309Septin Remodeling During Mammalian CytokinesisGiulia RussoMichael KraussCytokinesis mediates the final separation of a mother cell into two daughter cells. Septins are recruited to the cleavage furrow at an early stage. During cytokinetic progression the septin cytoskeleton is constantly rearranged, ultimately leading to a concentration of septins within the intercellular bridge (ICB), and to the formation of two rings adjacent to the midbody that aid ESCRT-dependent abscission. The molecular mechanisms underlying this behavior are poorly understood. Based on observations that septins can associate with actin, microtubules and associated motors, we review here established roles of septins in mammalian cytokinesis, and discuss, how septins may support cytokinetic progression by exerting their functions at particular sites. Finally, we discuss how this might be assisted by phosphoinositide-metabolizing enzymes.https://www.frontiersin.org/articles/10.3389/fcell.2021.768309/fullseptinscytokinesisactomyosinmicrotubulesphosphoinositides |
| spellingShingle | Giulia Russo Michael Krauss Septin Remodeling During Mammalian Cytokinesis Frontiers in Cell and Developmental Biology septins cytokinesis actomyosin microtubules phosphoinositides |
| title | Septin Remodeling During Mammalian Cytokinesis |
| title_full | Septin Remodeling During Mammalian Cytokinesis |
| title_fullStr | Septin Remodeling During Mammalian Cytokinesis |
| title_full_unstemmed | Septin Remodeling During Mammalian Cytokinesis |
| title_short | Septin Remodeling During Mammalian Cytokinesis |
| title_sort | septin remodeling during mammalian cytokinesis |
| topic | septins cytokinesis actomyosin microtubules phosphoinositides |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.768309/full |
| work_keys_str_mv | AT giuliarusso septinremodelingduringmammaliancytokinesis AT michaelkrauss septinremodelingduringmammaliancytokinesis |