Correlation Study between Serum Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke
BackgroundAssessment of the risks of stroke and then initiation of primary prevention are crucial to reducing the incidence rate of stroke. Trimethylamine-N-oxide (TMAO) is a recently discovered intestinal microbial metabolite, whose relationships with the risks of stroke have been rarely reported.O...
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Chinese General Practice Publishing House Co., Ltd
2022-03-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/1646123512979-1301105872.pdf |
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| author | LUO Jiaxin, ZHANG Aoqi, GAO Ruijiang, LI Ziru, ZHU Runxiu, YAO Yuan, YUAN Jun |
| author_facet | LUO Jiaxin, ZHANG Aoqi, GAO Ruijiang, LI Ziru, ZHU Runxiu, YAO Yuan, YUAN Jun |
| author_sort | LUO Jiaxin, ZHANG Aoqi, GAO Ruijiang, LI Ziru, ZHU Runxiu, YAO Yuan, YUAN Jun |
| collection | DOAJ |
| description | BackgroundAssessment of the risks of stroke and then initiation of primary prevention are crucial to reducing the incidence rate of stroke. Trimethylamine-N-oxide (TMAO) is a recently discovered intestinal microbial metabolite, whose relationships with the risks of stroke have been rarely reported.ObjectiveTo explore the correlation between serum TMAO levels and the risks of acute ischemic stroke (AIS) .MethodsWith the supporting by the project of the National Health Commission (stroke high risk population screening and intervention) , five hundred cases were randomly selected from the stroke screening population in the New Urban Community of Hohhot city of Inner Mongolia from October to December 2020. Finally, 399 cases were included according to the set of standard, and then the 399 cases were divided into normal control group (n=121) , moderate AIS risk group (n=141) , and high AIS risk group (n=137) in accordance with the screening results (score of stroke risk rated using a scoring card) . Demographic and laboratory indices (including serum TMAO detected using ELISA) of all cases were collected. Pearson correlation test and Spearman rank correlation test were conducted to measure the correlation of TMAO with AIS risks. Multinomial and ordinal Logistic regressions were used to explore the influencing factors of AIS risks. ROC analysis was used to estimate the predictive value of TMAO for AIS risk.ResultsCompared with the control group, the serum TMAO level in high-risk group was increased significantly (P<0.05) . Correlation analysis results found that serum TMAO level was negatively associated with increased age, being female, history of hypertension, diabetes history, current smoking and drinking consumption (r=-0.182, rs=-0.130, -0.262, -0.147, -0.178, -0.140, P<0.05) , but positively associated with lack of exercise and increased BMI (rs=0.153, r=0.210, P<0.05) .The multinomial and ordinal Logistic regression analyses showed that increased TMAO was independently associated with increased risk of AIS (B=3.084, SE=0.426, P<0.001) . The AUC of serum TMAO in predicting AIS risk was 0.790 〔95%CI (0.737, 0.837) 〕with 62.0% sensitivity and 91.6% specificity when its optimal cut-off value was determined as 3.28 μmol/L.ConclusionSerum TMAO level may be independently related to AIS, which could be used as a clinical predictor for AIS. |
| first_indexed | 2024-04-24T11:59:06Z |
| format | Article |
| id | doaj.art-d20918e9e84c4a24ac86fae54cefd712 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:59:06Z |
| publishDate | 2022-03-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
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| series | Zhongguo quanke yixue |
| spelling | doaj.art-d20918e9e84c4a24ac86fae54cefd7122024-04-09T02:52:28ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-03-0125091130113510.12114/j.issn.1007-9572.2021.02.125Correlation Study between Serum Trimethylamine-N-oxide and the Risk of Acute Ischemic StrokeLUO Jiaxin, ZHANG Aoqi, GAO Ruijiang, LI Ziru, ZHU Runxiu, YAO Yuan, YUAN Jun0 1.Inner Mongolia Clinical Medical College，Inner Mongolia Medical University，Hohhot 010107，China 2.Department of Neurology，Inner Mongolia People's Hospital，Hohhot 010010，China 3.School of Life Sciences，Inner Mongolia University，Hohhot 010070，China 4.Stroke Center，Inner Mongolia People's Hospital，Hohhot 010010，China *Corresponding author：YAO Yuan，Associate professor；E-mail：zhjyq129@163.com YUAN Jun，Professor；E-mail：13947108585@139.com BackgroundAssessment of the risks of stroke and then initiation of primary prevention are crucial to reducing the incidence rate of stroke. Trimethylamine-N-oxide (TMAO) is a recently discovered intestinal microbial metabolite, whose relationships with the risks of stroke have been rarely reported.ObjectiveTo explore the correlation between serum TMAO levels and the risks of acute ischemic stroke (AIS) .MethodsWith the supporting by the project of the National Health Commission (stroke high risk population screening and intervention) , five hundred cases were randomly selected from the stroke screening population in the New Urban Community of Hohhot city of Inner Mongolia from October to December 2020. Finally, 399 cases were included according to the set of standard, and then the 399 cases were divided into normal control group (n=121) , moderate AIS risk group (n=141) , and high AIS risk group (n=137) in accordance with the screening results (score of stroke risk rated using a scoring card) . Demographic and laboratory indices (including serum TMAO detected using ELISA) of all cases were collected. Pearson correlation test and Spearman rank correlation test were conducted to measure the correlation of TMAO with AIS risks. Multinomial and ordinal Logistic regressions were used to explore the influencing factors of AIS risks. ROC analysis was used to estimate the predictive value of TMAO for AIS risk.ResultsCompared with the control group, the serum TMAO level in high-risk group was increased significantly (P<0.05) . Correlation analysis results found that serum TMAO level was negatively associated with increased age, being female, history of hypertension, diabetes history, current smoking and drinking consumption (r=-0.182, rs=-0.130, -0.262, -0.147, -0.178, -0.140, P<0.05) , but positively associated with lack of exercise and increased BMI (rs=0.153, r=0.210, P<0.05) .The multinomial and ordinal Logistic regression analyses showed that increased TMAO was independently associated with increased risk of AIS (B=3.084, SE=0.426, P<0.001) . The AUC of serum TMAO in predicting AIS risk was 0.790 〔95%CI (0.737, 0.837) 〕with 62.0% sensitivity and 91.6% specificity when its optimal cut-off value was determined as 3.28 μmol/L.ConclusionSerum TMAO level may be independently related to AIS, which could be used as a clinical predictor for AIS.https://www.chinagp.net/fileup/1007-9572/PDF/1646123512979-1301105872.pdf|ischemic stroke|trimethylamine-n-oxide|risk of stroke|root cause analysis|forecasting |
| spellingShingle | LUO Jiaxin, ZHANG Aoqi, GAO Ruijiang, LI Ziru, ZHU Runxiu, YAO Yuan, YUAN Jun Correlation Study between Serum Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke Zhongguo quanke yixue |ischemic stroke|trimethylamine-n-oxide|risk of stroke|root cause analysis|forecasting |
| title | Correlation Study between Serum
Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke |
| title_full | Correlation Study between Serum
Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke |
| title_fullStr | Correlation Study between Serum
Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke |
| title_full_unstemmed | Correlation Study between Serum
Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke |
| title_short | Correlation Study between Serum
Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke |
| title_sort | correlation study between serum trimethylamine n oxide and the risk of acute ischemic stroke |
| topic | |ischemic stroke|trimethylamine-n-oxide|risk of stroke|root cause analysis|forecasting |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/1646123512979-1301105872.pdf |
| work_keys_str_mv | AT luojiaxinzhangaoqigaoruijiangliziruzhurunxiuyaoyuanyuanjun correlationstudybetweenserumtrimethylaminenoxideandtheriskofacuteischemicstroke |