Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. He...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/9/2939 |
| _version_ | 1797503674054868992 |
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| author | Syed Nasir Abbas Bukhari Hasan Ejaz Mervat A. Elsherif Nenad Janković |
| author_facet | Syed Nasir Abbas Bukhari Hasan Ejaz Mervat A. Elsherif Nenad Janković |
| author_sort | Syed Nasir Abbas Bukhari |
| collection | DOAJ |
| description | Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3<i>H</i>)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%). |
| first_indexed | 2024-03-10T03:54:05Z |
| format | Article |
| id | doaj.art-d20a03d8ed63427d942e7b5c01f47835 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:54:05Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d20a03d8ed63427d942e7b5c01f478352023-11-23T08:51:52ZengMDPI AGMolecules1420-30492022-05-01279293910.3390/molecules27092939Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli HybridsSyed Nasir Abbas Bukhari0Hasan Ejaz1Mervat A. Elsherif2Nenad Janković3Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi ArabiaChemistry Department, College of Science, Jouf University, Sakaka 72388, Saudi ArabiaDepartment of Science, Institute for Information Technologies Kragujevac, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, SerbiaDihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon–sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3<i>H</i>)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32–99%).https://www.mdpi.com/1420-3049/27/9/2939dihydrouracilBiginelli hybridsynthesistetrahydropyrimidine<i>m</i>-chloroperbenzoic acid |
| spellingShingle | Syed Nasir Abbas Bukhari Hasan Ejaz Mervat A. Elsherif Nenad Janković Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids Molecules dihydrouracil Biginelli hybrid synthesis tetrahydropyrimidine <i>m</i>-chloroperbenzoic acid |
| title | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
| title_full | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
| title_fullStr | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
| title_full_unstemmed | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
| title_short | Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids |
| title_sort | synthesis and characterization of dihydrouracil analogs utilizing biginelli hybrids |
| topic | dihydrouracil Biginelli hybrid synthesis tetrahydropyrimidine <i>m</i>-chloroperbenzoic acid |
| url | https://www.mdpi.com/1420-3049/27/9/2939 |
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