Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and Tibet
Purpose: This study aimed to explore the influence of high altitude on myopia, macular choroidal thickness (mCT), and macular retinal thickness (mRT) in adolescents. Methods: Two schools, one in Shanghai (at sea level) and one in Shigatse, Tibet (more than 4000 m above sea level), were selected. Ref...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=14;spage=240;epage=247;aulast=Cai |
| _version_ | 1797246480669474816 |
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| author | Chunyang Cai Yingyan Ma Shuai He Chunren Meng Chufeng Gu Jiangnan He Thashi Lhamo Deji Draga Chuandi Zhou Qinghua Qiu |
| author_facet | Chunyang Cai Yingyan Ma Shuai He Chunren Meng Chufeng Gu Jiangnan He Thashi Lhamo Deji Draga Chuandi Zhou Qinghua Qiu |
| author_sort | Chunyang Cai |
| collection | DOAJ |
| description | Purpose: This study aimed to explore the influence of high altitude on myopia, macular choroidal thickness (mCT), and macular retinal thickness (mRT) in adolescents. Methods: Two schools, one in Shanghai (at sea level) and one in Shigatse, Tibet (more than 4000 m above sea level), were selected. Refractive error was measured by an autorefractor instrument and subjective refraction, and mCT and mRT were measured at three concentric circles by optical coherence tomography. Student's t-test, Chi-square test, and multiple linear regression analyses were used to analyze the data. Results: A total of 1114 participants (657 and 457 in Shanghai and Tibet, respectively) were enrolled in this cross-sectional study. The average age of the participants was 18.81 ± 1.10 years, and 44.34% were males. The spherical equivalent (SE) of adolescents in Shanghai was significantly lower than that of adolescents in Tibet (-4.14 ± 2.37 D and -2.12 ± 1.87 D, P < 0.01). The prevalence of myopia and high myopia among adolescents in Shanghai (94.52%, 19.48%) was significantly higher than those among adolescents in Tibet (44.74%, 2.41%) (P < 0.01). The mCT of Tibetan adolescents was significantly thicker than that of Shanghai adolescents (295.80 ± 62.46 μm and 218.71 ± 61.42 μm, P < 0.01), especially the central mCT. The mRT of Tibetan adolescents was also thicker than that of Shanghai adolescents (301.42 ± 23.26 μm and 281.04 ± 12.24 μm, P < 0.01). Conclusions: Compared with Shanghai adolescents, the choroid of Tibet adolescents is thicker, and the myopia prevalence is lower. It is speculated that increased altitude is associated with the thickening of mCT and a low myopia prevalence. |
| first_indexed | 2024-04-24T19:43:28Z |
| format | Article |
| id | doaj.art-d20a80ec2b5c4a4fa50646e7f0707af6 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-24T19:43:28Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-d20a80ec2b5c4a4fa50646e7f0707af62024-03-25T10:29:00ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892024-01-01721424024710.4103/IJO.IJO_1546_23Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and TibetChunyang CaiYingyan MaShuai HeChunren MengChufeng GuJiangnan HeThashi LhamoDeji DragaChuandi ZhouQinghua QiuPurpose: This study aimed to explore the influence of high altitude on myopia, macular choroidal thickness (mCT), and macular retinal thickness (mRT) in adolescents. Methods: Two schools, one in Shanghai (at sea level) and one in Shigatse, Tibet (more than 4000 m above sea level), were selected. Refractive error was measured by an autorefractor instrument and subjective refraction, and mCT and mRT were measured at three concentric circles by optical coherence tomography. Student's t-test, Chi-square test, and multiple linear regression analyses were used to analyze the data. Results: A total of 1114 participants (657 and 457 in Shanghai and Tibet, respectively) were enrolled in this cross-sectional study. The average age of the participants was 18.81 ± 1.10 years, and 44.34% were males. The spherical equivalent (SE) of adolescents in Shanghai was significantly lower than that of adolescents in Tibet (-4.14 ± 2.37 D and -2.12 ± 1.87 D, P < 0.01). The prevalence of myopia and high myopia among adolescents in Shanghai (94.52%, 19.48%) was significantly higher than those among adolescents in Tibet (44.74%, 2.41%) (P < 0.01). The mCT of Tibetan adolescents was significantly thicker than that of Shanghai adolescents (295.80 ± 62.46 μm and 218.71 ± 61.42 μm, P < 0.01), especially the central mCT. The mRT of Tibetan adolescents was also thicker than that of Shanghai adolescents (301.42 ± 23.26 μm and 281.04 ± 12.24 μm, P < 0.01). Conclusions: Compared with Shanghai adolescents, the choroid of Tibet adolescents is thicker, and the myopia prevalence is lower. It is speculated that increased altitude is associated with the thickening of mCT and a low myopia prevalence.http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=14;spage=240;epage=247;aulast=Caiadolescentschoroidal thicknesshigh altitudemyopiaretinal thickness |
| spellingShingle | Chunyang Cai Yingyan Ma Shuai He Chunren Meng Chufeng Gu Jiangnan He Thashi Lhamo Deji Draga Chuandi Zhou Qinghua Qiu Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and Tibet Indian Journal of Ophthalmology adolescents choroidal thickness high altitude myopia retinal thickness |
| title | Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and Tibet |
| title_full | Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and Tibet |
| title_fullStr | Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and Tibet |
| title_full_unstemmed | Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and Tibet |
| title_short | Influence of high altitude on choroid thickness, retinal thickness, and myopia: A cross-sectional study comparing adolescents in Shanghai and Tibet |
| title_sort | influence of high altitude on choroid thickness retinal thickness and myopia a cross sectional study comparing adolescents in shanghai and tibet |
| topic | adolescents choroidal thickness high altitude myopia retinal thickness |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=14;spage=240;epage=247;aulast=Cai |
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