Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil
Background: COVID-19 is usually milder in children and adolescents, leading to lower hospital admission rates than adults. This study evaluated clinical manifestations in children (< 10 years) and adolescents (10 to < 18 years) with COVID-19 admitted to a tertiary municipal hospital in Rio de...
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| Format: | Article |
| Language: | English |
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Universidad Nacional Hermilio Valdizán de Huánuco
2024-02-01
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| Series: | Microbes, Infection and Chemotherapy |
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| Online Access: | https://revistas.unheval.edu.pe/index.php/mic/article/view/1989 |
| _version_ | 1797270802051104768 |
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| author | Jeferson Tobias da Silva de Oliveira de Oliveira Luciana Fernandes Portela Marcelo Carvalho Vieira Mariana Cristina Mendes Almeida Luiz Henrique Conde Sangenis Ivonete Siviero Tatiana Rehder Gonçalves Mauro Mediano |
| author_facet | Jeferson Tobias da Silva de Oliveira de Oliveira Luciana Fernandes Portela Marcelo Carvalho Vieira Mariana Cristina Mendes Almeida Luiz Henrique Conde Sangenis Ivonete Siviero Tatiana Rehder Gonçalves Mauro Mediano |
| author_sort | Jeferson Tobias da Silva de Oliveira de Oliveira |
| collection | DOAJ |
| description |
Background: COVID-19 is usually milder in children and adolescents, leading to lower hospital admission rates than adults. This study evaluated clinical manifestations in children (< 10 years) and adolescents (10 to < 18 years) with COVID-19 admitted to a tertiary municipal hospital in Rio de Janeiro (Brazil) during the first (February to November 2020) and second pandemic waves (November 2020 to April 2021). Methods: this retrospective observational study considered patients in the pediatric age group (<18 years old) with confirmed diagnosis of COVID-19 using RT-PCR. Descriptive and bivariate analysis were performed assuming a p-value<0.05 level of significance for all analyses. Results: among the 34 included patients (50% boys; 73.5% children), the most prevalent symptom was fever (88.2%), followed by asthenia (85.3%), and cough associated with dyspnea (50%); 29.4% were admitted to the ICU, and 5.9% needed invasive mechanical ventilation. All patients were treated with antibiotics, 88.2% with antivirals, and 52.9% with corticosteroids. Asthenia was more frequent among children than adolescents (96.0% vs. 55.6%; p < 0.01). Tuberculosis was observed in none of the children, but 33.3% of the adolescents (p-value = 0.003). The percentage of hospitalized patients with family members infected with SARS-CoV-2 was smaller among children than adolescents (8.0% vs. 44.0%; p-value = 0.01). Other variables that differed between children and adolescents were C-reactive protein, creatinine, and need for non-invasive mechanical ventilation. There were no deaths among participants. Conclusion: in our hospital, COVID-19 was most often not severe in children and adolescents. Overall, children were hospitalized more frequently by COVID-19 than adolescents, with some differences for clinical characteristics.
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| first_indexed | 2024-03-07T14:14:59Z |
| format | Article |
| id | doaj.art-d20c00800f3446ec933c9ae015535aa3 |
| institution | Directory Open Access Journal |
| issn | 2789-4274 |
| language | English |
| last_indexed | 2024-04-25T02:10:03Z |
| publishDate | 2024-02-01 |
| publisher | Universidad Nacional Hermilio Valdizán de Huánuco |
| record_format | Article |
| series | Microbes, Infection and Chemotherapy |
| spelling | doaj.art-d20c00800f3446ec933c9ae015535aa32024-03-07T13:33:30ZengUniversidad Nacional Hermilio Valdizán de HuánucoMicrobes, Infection and Chemotherapy2789-42742024-02-01410.54034/mic.e1989Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, BrazilJeferson Tobias da Silva de Oliveira de Oliveira0Luciana Fernandes Portela1Marcelo Carvalho Vieira2Mariana Cristina Mendes Almeida3Luiz Henrique Conde Sangenis4Ivonete Siviero5Tatiana Rehder Gonçalves6Mauro Mediano7Hospital Municipal Jesus, Pediatric Surgery Service, Rio de Janeiro/RJ, Brazil.Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro/RJ, Brazil.Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro/RJ, Brazil.Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro/RJ, Brazil.Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro/RJ, Brazil.Universidade Federal do Rio de Janeiro, Surgery Department, Rio de Janeiro/RJ, Brazil.Universidade Federal do Rio de Janeiro, Instituto de Estudos em Saúde Coletiva, Rio de Janeiro/RJ, Brazil.Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro/RJ, Brazil. Background: COVID-19 is usually milder in children and adolescents, leading to lower hospital admission rates than adults. This study evaluated clinical manifestations in children (< 10 years) and adolescents (10 to < 18 years) with COVID-19 admitted to a tertiary municipal hospital in Rio de Janeiro (Brazil) during the first (February to November 2020) and second pandemic waves (November 2020 to April 2021). Methods: this retrospective observational study considered patients in the pediatric age group (<18 years old) with confirmed diagnosis of COVID-19 using RT-PCR. Descriptive and bivariate analysis were performed assuming a p-value<0.05 level of significance for all analyses. Results: among the 34 included patients (50% boys; 73.5% children), the most prevalent symptom was fever (88.2%), followed by asthenia (85.3%), and cough associated with dyspnea (50%); 29.4% were admitted to the ICU, and 5.9% needed invasive mechanical ventilation. All patients were treated with antibiotics, 88.2% with antivirals, and 52.9% with corticosteroids. Asthenia was more frequent among children than adolescents (96.0% vs. 55.6%; p < 0.01). Tuberculosis was observed in none of the children, but 33.3% of the adolescents (p-value = 0.003). The percentage of hospitalized patients with family members infected with SARS-CoV-2 was smaller among children than adolescents (8.0% vs. 44.0%; p-value = 0.01). Other variables that differed between children and adolescents were C-reactive protein, creatinine, and need for non-invasive mechanical ventilation. There were no deaths among participants. Conclusion: in our hospital, COVID-19 was most often not severe in children and adolescents. Overall, children were hospitalized more frequently by COVID-19 than adolescents, with some differences for clinical characteristics. https://revistas.unheval.edu.pe/index.php/mic/article/view/1989childrenadolescentsCOVID-19SARS-CoV-2symptomsmortality |
| spellingShingle | Jeferson Tobias da Silva de Oliveira de Oliveira Luciana Fernandes Portela Marcelo Carvalho Vieira Mariana Cristina Mendes Almeida Luiz Henrique Conde Sangenis Ivonete Siviero Tatiana Rehder Gonçalves Mauro Mediano Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil Microbes, Infection and Chemotherapy children adolescents COVID-19 SARS-CoV-2 symptoms mortality |
| title | Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil |
| title_full | Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil |
| title_fullStr | Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil |
| title_full_unstemmed | Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil |
| title_short | Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil |
| title_sort | clinical profile during the first and second pandemic waves in children and adolescents with covid 19 at pediatric public hospital rio de janeiro brazil |
| topic | children adolescents COVID-19 SARS-CoV-2 symptoms mortality |
| url | https://revistas.unheval.edu.pe/index.php/mic/article/view/1989 |
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