Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool
Introduction Mozambique suffers from regular floods along its principal river basins and periodic cyclones that resulted in several cholera epidemics during the last decades. Cholera outbreaks in the recent 5 years affected particularly the northern provinces of the country including Nampula and Nia...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/9/e053585.full |
| _version_ | 1818051362409152512 |
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| author | Se Eun Park Florian Marks Vittal Mogasale Jucunú J Elias Chitio Cynthia S Baltazar José Paulo Langa Liliana Dengo Baloi Ramos B J Mboane José Alberto Manuel Sadate Assane Alide Omar Mariana Manso Igor Capitine Craig Van Rensburg Naira Luiz Namseon S Beck |
| author_facet | Se Eun Park Florian Marks Vittal Mogasale Jucunú J Elias Chitio Cynthia S Baltazar José Paulo Langa Liliana Dengo Baloi Ramos B J Mboane José Alberto Manuel Sadate Assane Alide Omar Mariana Manso Igor Capitine Craig Van Rensburg Naira Luiz Namseon S Beck |
| author_sort | Se Eun Park |
| collection | DOAJ |
| description | Introduction Mozambique suffers from regular floods along its principal river basins and periodic cyclones that resulted in several cholera epidemics during the last decades. Cholera outbreaks in the recent 5 years affected particularly the northern provinces of the country including Nampula and Niassa provinces. A pre-emptive oral cholera vaccine (OCV) mass vaccination campaign was conducted in Cuamba District, Niassa Province, and the feasibility, costs, and vaccination coverage assessed.Methods WHO prequalified OCV (Euvichol-Plus), a killed whole-cell bivalent vaccine containing Vibrio cholerae O1 (classical and El Tor) and O139, was administered in two doses with a 15-day interval during 7–31 August 2018, targeting around 180 000 people aged above 1 year in Cuamba District. Microplanning, community sensitisation, and training of local public health professionals and field enumerators were conducted. Feasibility and costs of vaccination were assessed using CholTool. Vaccination coverage and barriers were assessed through community surveys.Results The administrative coverage of the first and second rounds of the campaign were 98.9% (194 581) and 98.8% (194 325), respectively, based on the available population data that estimated total 196 652 inhabitants in the target area. The vaccination coverage survey exhibited 75.9% (±2.2%) and 68.5% (±3.3%) coverage for the first and second rounds, respectively. Overall, 60.4% (±3.4%) of the target population received full two doses of OCV. Barriers to vaccination included incompatibility between working hours and campaign time. No severe adverse events were notified. The total financial cost per dose delivered was US$0.60 without vaccine cost and US$1.98 including vaccine costs.Conclusion The pre-emptive OCV mass vaccination campaign in remote setting in Mozambique was feasible with reasonable full-dose vaccination coverage to confer sufficient herd immunity for at least the next 3 to 5 years. The delivery cost estimate indicates that the OCV campaign is affordable as it is comparable with Gavi’s operational support for vaccination campaigns. |
| first_indexed | 2024-12-10T11:08:10Z |
| format | Article |
| id | doaj.art-d20d68f8179744a5b2617806593ccfd8 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-12-10T11:08:10Z |
| publishDate | 2022-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-d20d68f8179744a5b2617806593ccfd82022-12-22T01:51:30ZengBMJ Publishing GroupBMJ Open2044-60552022-09-0112910.1136/bmjopen-2021-053585Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholToolSe Eun Park0Florian Marks1Vittal Mogasale2Jucunú J Elias Chitio3Cynthia S Baltazar4José Paulo Langa5Liliana Dengo Baloi6Ramos B J Mboane7José Alberto Manuel8Sadate Assane9Alide Omar10Mariana Manso11Igor Capitine12Craig Van Rensburg13Naira Luiz14Namseon S Beck15Clinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute, Seoul, Republic of KoreaEpidemology, Public Health, Impact (EPIC) Unit, International Vaccine Institute, Seoul, Republic of KoreaPolicy and Economic Research Department, International Vaccine Institute, Seoul, Republic of KoreaNational Department for Surveillance and Surveys in Health, National Institute of Health, Maputo, MozambiqueNational Department for Surveillance and Surveys in Health, National Institute of Health, Maputo, MozambiqueNational Department for Surveillance and Surveys in Health, National Institute of Health, Maputo, MozambiqueNational Department for Surveillance and Surveys in Health, National Institute of Health, Maputo, MozambiqueProvincial Directorate of Health, Lichinga City, MozambiqueProvincial Directorate of Health, Lichinga City, MozambiqueProvincial Directorate of Health, Lichinga City, MozambiqueDistrict Health Directorate, Cuamba District, MozambiqueDistrict Health Directorate, Cuamba District, MozambiqueNational Department for Surveillance and Surveys in Health, National Institute of Health, Maputo, MozambiquePolicy and Economic Research Department, International Vaccine Institute, Seoul, Republic of KoreaNational Department for Surveillance and Surveys in Health, National Institute of Health, Maputo, MozambiqueClinical, Assessment, Regulatory, Evaluation (CARE) Unit, International Vaccine Institute, Seoul, Republic of KoreaIntroduction Mozambique suffers from regular floods along its principal river basins and periodic cyclones that resulted in several cholera epidemics during the last decades. Cholera outbreaks in the recent 5 years affected particularly the northern provinces of the country including Nampula and Niassa provinces. A pre-emptive oral cholera vaccine (OCV) mass vaccination campaign was conducted in Cuamba District, Niassa Province, and the feasibility, costs, and vaccination coverage assessed.Methods WHO prequalified OCV (Euvichol-Plus), a killed whole-cell bivalent vaccine containing Vibrio cholerae O1 (classical and El Tor) and O139, was administered in two doses with a 15-day interval during 7–31 August 2018, targeting around 180 000 people aged above 1 year in Cuamba District. Microplanning, community sensitisation, and training of local public health professionals and field enumerators were conducted. Feasibility and costs of vaccination were assessed using CholTool. Vaccination coverage and barriers were assessed through community surveys.Results The administrative coverage of the first and second rounds of the campaign were 98.9% (194 581) and 98.8% (194 325), respectively, based on the available population data that estimated total 196 652 inhabitants in the target area. The vaccination coverage survey exhibited 75.9% (±2.2%) and 68.5% (±3.3%) coverage for the first and second rounds, respectively. Overall, 60.4% (±3.4%) of the target population received full two doses of OCV. Barriers to vaccination included incompatibility between working hours and campaign time. No severe adverse events were notified. The total financial cost per dose delivered was US$0.60 without vaccine cost and US$1.98 including vaccine costs.Conclusion The pre-emptive OCV mass vaccination campaign in remote setting in Mozambique was feasible with reasonable full-dose vaccination coverage to confer sufficient herd immunity for at least the next 3 to 5 years. The delivery cost estimate indicates that the OCV campaign is affordable as it is comparable with Gavi’s operational support for vaccination campaigns.https://bmjopen.bmj.com/content/12/9/e053585.full |
| spellingShingle | Se Eun Park Florian Marks Vittal Mogasale Jucunú J Elias Chitio Cynthia S Baltazar José Paulo Langa Liliana Dengo Baloi Ramos B J Mboane José Alberto Manuel Sadate Assane Alide Omar Mariana Manso Igor Capitine Craig Van Rensburg Naira Luiz Namseon S Beck Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool BMJ Open |
| title | Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool |
| title_full | Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool |
| title_fullStr | Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool |
| title_full_unstemmed | Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool |
| title_short | Pre-emptive oral cholera vaccine (OCV) mass vaccination campaign in Cuamba District, Niassa Province, Mozambique: feasibility, vaccination coverage and delivery costs using CholTool |
| title_sort | pre emptive oral cholera vaccine ocv mass vaccination campaign in cuamba district niassa province mozambique feasibility vaccination coverage and delivery costs using choltool |
| url | https://bmjopen.bmj.com/content/12/9/e053585.full |
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