Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid–Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration

Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid–Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration

The methacrylic acid–ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume, time, and stirring speed, while size, PDI, ze...

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Bibliographic Details
Main Authors: Omar Rodrigo Guadarrama-Escobar, Ivonne Sánchez-Vázquez, Pablo Serrano-Castañeda, German Alberto Chamorro-Cevallos, Isabel Marlen Rodríguez-Cruz, Adalí Yisell Sánchez-Padrón, Ericka Anguiano-Almazán, Ma. Concepción Peña-Juárez, Abraham Méndez-Albores, Clara Luisa Domínguez-Delgado, Crisóforo Mercado-Márquez, Betsabé Rodríguez-Pérez, José Juan Escobar-Chávez
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
methacrylic acid–ethyl acrylate copolymer nanoparticles
polymeric nanoparticles
glibenclamide
polioxyl 40 hydrogenated castor oil
diabetes mellitus
glucose control
Online Access:https://www.mdpi.com/1999-4923/13/12/2023

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