Mending a broken heart with novel cardiogenic small molecules
Abstract Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-05-01
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| Series: | Cell Regeneration |
| Online Access: | https://doi.org/10.1186/s13619-022-00120-z |
| _version_ | 1818251071518146560 |
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| author | Nevan Powers Guo N. Huang |
| author_facet | Nevan Powers Guo N. Huang |
| author_sort | Nevan Powers |
| collection | DOAJ |
| description | Abstract Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis. The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency, and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry. |
| first_indexed | 2024-12-12T16:02:27Z |
| format | Article |
| id | doaj.art-d20da87b31c74f439290a3e26180c848 |
| institution | Directory Open Access Journal |
| issn | 2045-9769 |
| language | English |
| last_indexed | 2024-12-12T16:02:27Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj.art-d20da87b31c74f439290a3e26180c8482022-12-22T00:19:23ZengSpringerOpenCell Regeneration2045-97692022-05-011111410.1186/s13619-022-00120-zMending a broken heart with novel cardiogenic small moleculesNevan Powers0Guo N. Huang1Cardiovascular Research Institute & Department of Physiology, University of California, San FranciscoCardiovascular Research Institute & Department of Physiology, University of California, San FranciscoAbstract Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis. The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency, and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry.https://doi.org/10.1186/s13619-022-00120-z |
| spellingShingle | Nevan Powers Guo N. Huang Mending a broken heart with novel cardiogenic small molecules Cell Regeneration |
| title | Mending a broken heart with novel cardiogenic small molecules |
| title_full | Mending a broken heart with novel cardiogenic small molecules |
| title_fullStr | Mending a broken heart with novel cardiogenic small molecules |
| title_full_unstemmed | Mending a broken heart with novel cardiogenic small molecules |
| title_short | Mending a broken heart with novel cardiogenic small molecules |
| title_sort | mending a broken heart with novel cardiogenic small molecules |
| url | https://doi.org/10.1186/s13619-022-00120-z |
| work_keys_str_mv | AT nevanpowers mendingabrokenheartwithnovelcardiogenicsmallmolecules AT guonhuang mendingabrokenheartwithnovelcardiogenicsmallmolecules |