Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA
Background Two new SNPs have been recently associated to Alzheimer’s disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G. The risk of Alzheimer’s disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association...
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| Format: | Article |
| Language: | English |
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Medwave Estudios Limitada
2024-02-01
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| Series: | Medwave |
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| Online Access: | https://www.medwave.cl/revisiones/analisis/2754.html |
| _version_ | 1827324948672151552 |
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| author | Alejandro Levi-Monsalve Sergio Vladimir Flores Germán Manriquez |
| author_facet | Alejandro Levi-Monsalve Sergio Vladimir Flores Germán Manriquez |
| author_sort | Alejandro Levi-Monsalve |
| collection | DOAJ |
| description | Background Two new SNPs have been recently associated to Alzheimer’s disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G. The risk of Alzheimer’s disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association between these and other single nucleotide polymorphisms (SNPs) has not been assessed.
Methods Linkage disequilibrium analysis, with r= 0.8 as a threshold value, was used to impute new candidate SNPs, on genomic data from both genes in 26 populations worldwide (n= 2504) from the 1000Genomes database.
Results Four SNPs (rs13376485, rs3767640, rs3767639 and rs3767641) were linked to rs1050501 and one (rs2405442) to rs1859788 in the whole sample.
Conclusions Five novel SNPs could be associated with Alzheimer’s disease susceptibility and play a causal role, even if none of them are exon variants since their potential roles in the regulation of gene expression. |
| first_indexed | 2024-03-07T14:07:19Z |
| format | Article |
| id | doaj.art-d212f89f2e474a1bbfa1d7676dd5649a |
| institution | Directory Open Access Journal |
| issn | 0717-6384 |
| language | English |
| last_indexed | 2024-03-07T14:07:19Z |
| publishDate | 2024-02-01 |
| publisher | Medwave Estudios Limitada |
| record_format | Article |
| series | Medwave |
| spelling | doaj.art-d212f89f2e474a1bbfa1d7676dd5649a2024-03-06T19:14:05ZengMedwave Estudios LimitadaMedwave0717-63842024-02-012401e2754e275410.5867/medwave.2024.01.2754Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRAAlejandro Levi-Monsalve0https://orcid.org/0000-0002-5025-3095Sergio Vladimir Flores1https://orcid.org/0000-0002-6911-4597Germán Manriquez2https://orcid.org/0000-0002-3376-8804Departamento de Antropología, Universidad de Chile, ChileUniversidad Arturo Prat, Iquique, ChileCentre for Quantitative Analysis in Dental Anthropology (CA2), Faculty of Dentistry, Universidad de Chile, Santiago, ChileBackground Two new SNPs have been recently associated to Alzheimer’s disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G. The risk of Alzheimer’s disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association between these and other single nucleotide polymorphisms (SNPs) has not been assessed. Methods Linkage disequilibrium analysis, with r= 0.8 as a threshold value, was used to impute new candidate SNPs, on genomic data from both genes in 26 populations worldwide (n= 2504) from the 1000Genomes database. Results Four SNPs (rs13376485, rs3767640, rs3767639 and rs3767641) were linked to rs1050501 and one (rs2405442) to rs1859788 in the whole sample. Conclusions Five novel SNPs could be associated with Alzheimer’s disease susceptibility and play a causal role, even if none of them are exon variants since their potential roles in the regulation of gene expression.https://www.medwave.cl/revisiones/analisis/2754.htmlalzheimer’s diseaselinkage disequilibriumgenetic association studiessingle nucleotide polymorphismsfcgriibpilra |
| spellingShingle | Alejandro Levi-Monsalve Sergio Vladimir Flores Germán Manriquez Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA Medwave alzheimer’s disease linkage disequilibrium genetic association studies single nucleotide polymorphisms fcgriib pilra |
| title | Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA |
| title_full | Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA |
| title_fullStr | Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA |
| title_full_unstemmed | Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA |
| title_short | Nuevos SNP candidatos para la asociación genética con la enfermedad de Alzheimer: un análisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA |
| title_sort | nuevos snp candidatos para la asociacion genetica con la enfermedad de alzheimer un analisis de desequilibrio de ligamiento para los genes fcgriib y pilra |
| topic | alzheimer’s disease linkage disequilibrium genetic association studies single nucleotide polymorphisms fcgriib pilra |
| url | https://www.medwave.cl/revisiones/analisis/2754.html |
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