Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation

Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation

Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and produces behavioral nociception via the cation channel transient receptor potential ankyrin 1 (TRPA1). However, rigorous...

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Bibliographic Details
Main Authors: Ryan B. Griggs, Don E. Laird, Renee R. Donahue, Weisi Fu, Bradley K. Taylor
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Neuroscience
Subjects:
methylglyoxal
TRPA1
AC1
pain
diabetes
peripheral
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00679/full

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