The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review
Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are critical neurological conditions that necessitate specialized care in the Intensive Care Unit (ICU). Managing cerebral perfusion pressure (CPP) and mean arterial pressure (MAP) is of primary importance in these patients. To maintain...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/2/117 |
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| author | Michele Salvagno Federico Geraldini Giacomo Coppalini Chiara Robba Elisa Gouvea Bogossian Filippo Annoni Eva Vitali Elda Diletta Sterchele Costantino Balestra Fabio Silvio Taccone |
| author_facet | Michele Salvagno Federico Geraldini Giacomo Coppalini Chiara Robba Elisa Gouvea Bogossian Filippo Annoni Eva Vitali Elda Diletta Sterchele Costantino Balestra Fabio Silvio Taccone |
| author_sort | Michele Salvagno |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are critical neurological conditions that necessitate specialized care in the Intensive Care Unit (ICU). Managing cerebral perfusion pressure (CPP) and mean arterial pressure (MAP) is of primary importance in these patients. To maintain targeted MAP and CPP, vasopressors and/or inotropes are commonly used. However, their effects on cerebral oxygenation are not fully understood. The aim of this review is to provide an up-to date review regarding the current uses and pathophysiological issues related to the use of vasopressors and inotropes in TBI and SAH patients. According to our findings, despite achieving similar hemodynamic parameters and CPP, the effects of various vasopressors and inotropes on cerebral oxygenation, local CBF and metabolism are heterogeneous. Therefore, a more accurate understanding of the cerebral activity of these medications is crucial for optimizing patient management in the ICU setting. |
| first_indexed | 2024-03-07T22:40:05Z |
| format | Article |
| id | doaj.art-d216c5cbffa94b62862834064ff93c2c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-07T22:40:05Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d216c5cbffa94b62862834064ff93c2c2024-02-23T15:09:38ZengMDPI AGBrain Sciences2076-34252024-01-0114211710.3390/brainsci14020117The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative ReviewMichele Salvagno0Federico Geraldini1Giacomo Coppalini2Chiara Robba3Elisa Gouvea Bogossian4Filippo Annoni5Eva Vitali6Elda Diletta Sterchele7Costantino Balestra8Fabio Silvio Taccone9Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumDepartment of Anesthesia and Intensive Care, Ospedale Università di Padova, 35128 Padova, ItalyDepartment of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, 20089 Milano, ItalyAnaesthesia and Intensive Care, IRCCS Policlinico San Martino, 16132 Genova, ItalyDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumDepartment Environmental, Occupational, Aging (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), 1160 Brussels, BelgiumDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumTraumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are critical neurological conditions that necessitate specialized care in the Intensive Care Unit (ICU). Managing cerebral perfusion pressure (CPP) and mean arterial pressure (MAP) is of primary importance in these patients. To maintain targeted MAP and CPP, vasopressors and/or inotropes are commonly used. However, their effects on cerebral oxygenation are not fully understood. The aim of this review is to provide an up-to date review regarding the current uses and pathophysiological issues related to the use of vasopressors and inotropes in TBI and SAH patients. According to our findings, despite achieving similar hemodynamic parameters and CPP, the effects of various vasopressors and inotropes on cerebral oxygenation, local CBF and metabolism are heterogeneous. Therefore, a more accurate understanding of the cerebral activity of these medications is crucial for optimizing patient management in the ICU setting.https://www.mdpi.com/2076-3425/14/2/117vasopressorsinotropestraumatic brain injurysubarachnoid hemorrhagebrain injuriesbrain oxygenation |
| spellingShingle | Michele Salvagno Federico Geraldini Giacomo Coppalini Chiara Robba Elisa Gouvea Bogossian Filippo Annoni Eva Vitali Elda Diletta Sterchele Costantino Balestra Fabio Silvio Taccone The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review Brain Sciences vasopressors inotropes traumatic brain injury subarachnoid hemorrhage brain injuries brain oxygenation |
| title | The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review |
| title_full | The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review |
| title_fullStr | The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review |
| title_full_unstemmed | The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review |
| title_short | The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review |
| title_sort | impact of inotropes and vasopressors on cerebral oxygenation in patients with traumatic brain injury and subarachnoid hemorrhage a narrative review |
| topic | vasopressors inotropes traumatic brain injury subarachnoid hemorrhage brain injuries brain oxygenation |
| url | https://www.mdpi.com/2076-3425/14/2/117 |
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