Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication
Lassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly prevalent in West Africa. Over the past few years, a significant amount of novel information has been provided on cellular factors that are determina...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/8/1/17 |
| _version_ | 1811299761364402176 |
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| author | María Eugenia Loureiro Alejandra D’Antuono Nora López |
| author_facet | María Eugenia Loureiro Alejandra D’Antuono Nora López |
| author_sort | María Eugenia Loureiro |
| collection | DOAJ |
| description | Lassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly prevalent in West Africa. Over the past few years, a significant amount of novel information has been provided on cellular factors that are determinant elements playing a role in arenavirus multiplication. In this review, we focus on host proteins that intersect with the initial steps of the LASV replication cycle: virus entry and genome replication. A better understanding of relevant virus⁻host interactions essential for sustaining these critical steps may help to identify possible targets for the rational design of novel therapeutic approaches against LASV and other arenaviruses that cause severe human disease. |
| first_indexed | 2024-04-13T06:40:37Z |
| format | Article |
| id | doaj.art-d217adbff381497893bb868b8d381730 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-13T06:40:37Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-d217adbff381497893bb868b8d3817302022-12-22T02:57:45ZengMDPI AGPathogens2076-08172019-01-01811710.3390/pathogens8010017pathogens8010017Virus–Host Interactions Involved in Lassa Virus Entry and Genome ReplicationMaría Eugenia Loureiro0Alejandra D’Antuono1Nora López2Centro de Virología Animal (CEVAN), CONICET-SENASA, Av Sir Alexander Fleming 1653, Martínez, Provincia de Buenos Aires B1640CSI, ArgentinaCentro de Virología Animal (CEVAN), CONICET-SENASA, Av Sir Alexander Fleming 1653, Martínez, Provincia de Buenos Aires B1640CSI, ArgentinaCentro de Virología Animal (CEVAN), CONICET-SENASA, Av Sir Alexander Fleming 1653, Martínez, Provincia de Buenos Aires B1640CSI, ArgentinaLassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly prevalent in West Africa. Over the past few years, a significant amount of novel information has been provided on cellular factors that are determinant elements playing a role in arenavirus multiplication. In this review, we focus on host proteins that intersect with the initial steps of the LASV replication cycle: virus entry and genome replication. A better understanding of relevant virus⁻host interactions essential for sustaining these critical steps may help to identify possible targets for the rational design of novel therapeutic approaches against LASV and other arenaviruses that cause severe human disease.https://www.mdpi.com/2076-0817/8/1/17Lassa feverarenavirusLASVvirus–host interactionsentryreplication |
| spellingShingle | María Eugenia Loureiro Alejandra D’Antuono Nora López Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication Pathogens Lassa fever arenavirus LASV virus–host interactions entry replication |
| title | Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication |
| title_full | Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication |
| title_fullStr | Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication |
| title_full_unstemmed | Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication |
| title_short | Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication |
| title_sort | virus host interactions involved in lassa virus entry and genome replication |
| topic | Lassa fever arenavirus LASV virus–host interactions entry replication |
| url | https://www.mdpi.com/2076-0817/8/1/17 |
| work_keys_str_mv | AT mariaeugenialoureiro virushostinteractionsinvolvedinlassavirusentryandgenomereplication AT alejandradantuono virushostinteractionsinvolvedinlassavirusentryandgenomereplication AT noralopez virushostinteractionsinvolvedinlassavirusentryandgenomereplication |