Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse Voltammetry
Herein, the detection of aspartic acid by doped Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod materials was proposed using differential pulse voltammetry. The nano-composite metal oxide was synthesized by the wet precipitation method in basic media. Aspartic acid is a non-essential...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/1/88 |
| _version_ | 1797445363489046528 |
|---|---|
| author | Sulaiman Y. Alfaifi Waheed Abiodun Adeosun Abdullah M. Asiri Mohammed M. Rahman |
| author_facet | Sulaiman Y. Alfaifi Waheed Abiodun Adeosun Abdullah M. Asiri Mohammed M. Rahman |
| author_sort | Sulaiman Y. Alfaifi |
| collection | DOAJ |
| description | Herein, the detection of aspartic acid by doped Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod materials was proposed using differential pulse voltammetry. The nano-composite metal oxide was synthesized by the wet precipitation method in basic media. Aspartic acid is a non-essential amino acid naturally synthesized in the body with lot of health significance, including as a biomarker for several health deficiencies. The synthesized composite Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod was well-investigated by using FESEM, XRD, XPS, FTIR, UV/vis., EIS, and CV. The synthesized composite exhibited a low limit of detection (0.03 µM, high sensitivity (0.0014 µA µM<sup>−1</sup> cm<sup>−2</sup>) and wide linear range (0.05–50 µM) for aspartic acid. The substrate, the Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod, enhanced the electro-catalytic oxidation of aspartic acid as a result of its catalytic and conductivity properties. The developed sensor based on Co<sub>3</sub>O<sub>4</sub>-ZnO has a repeatable, reproducible and stable current response for aspartic acid. Additionally, other electroactive compounds did not interfere with the sensor’s current response. The suitability of the developed sensor for real sample analysis was also established. Therefore, this study proposed the potential use of Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod material in healthcare management for the maintenance of human well-being. |
| first_indexed | 2024-03-09T13:25:41Z |
| format | Article |
| id | doaj.art-d2180ec856db4e3aa26793358ca3185a |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:25:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-d2180ec856db4e3aa26793358ca3185a2023-11-30T21:25:19ZengMDPI AGBiosensors2079-63742023-01-011318810.3390/bios13010088Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse VoltammetrySulaiman Y. Alfaifi0Waheed Abiodun Adeosun1Abdullah M. Asiri2Mohammed M. Rahman3Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaChemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaChemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaChemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaHerein, the detection of aspartic acid by doped Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod materials was proposed using differential pulse voltammetry. The nano-composite metal oxide was synthesized by the wet precipitation method in basic media. Aspartic acid is a non-essential amino acid naturally synthesized in the body with lot of health significance, including as a biomarker for several health deficiencies. The synthesized composite Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod was well-investigated by using FESEM, XRD, XPS, FTIR, UV/vis., EIS, and CV. The synthesized composite exhibited a low limit of detection (0.03 µM, high sensitivity (0.0014 µA µM<sup>−1</sup> cm<sup>−2</sup>) and wide linear range (0.05–50 µM) for aspartic acid. The substrate, the Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod, enhanced the electro-catalytic oxidation of aspartic acid as a result of its catalytic and conductivity properties. The developed sensor based on Co<sub>3</sub>O<sub>4</sub>-ZnO has a repeatable, reproducible and stable current response for aspartic acid. Additionally, other electroactive compounds did not interfere with the sensor’s current response. The suitability of the developed sensor for real sample analysis was also established. Therefore, this study proposed the potential use of Co<sub>3</sub>O<sub>4</sub>-ZnO nanorod material in healthcare management for the maintenance of human well-being.https://www.mdpi.com/2079-6374/13/1/88Co<sub>3</sub>O<sub>4</sub>-ZnO nanorodsaspartic acidelectrochemical methodsensitivityhealthcare safety |
| spellingShingle | Sulaiman Y. Alfaifi Waheed Abiodun Adeosun Abdullah M. Asiri Mohammed M. Rahman Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse Voltammetry Biosensors Co<sub>3</sub>O<sub>4</sub>-ZnO nanorods aspartic acid electrochemical method sensitivity healthcare safety |
| title | Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse Voltammetry |
| title_full | Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse Voltammetry |
| title_fullStr | Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse Voltammetry |
| title_full_unstemmed | Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse Voltammetry |
| title_short | Sensitive and Rapid Detection of Aspartic Acid with Co<sub>3</sub>O<sub>4</sub>-ZnO Nanorods Using Differential Pulse Voltammetry |
| title_sort | sensitive and rapid detection of aspartic acid with co sub 3 sub o sub 4 sub zno nanorods using differential pulse voltammetry |
| topic | Co<sub>3</sub>O<sub>4</sub>-ZnO nanorods aspartic acid electrochemical method sensitivity healthcare safety |
| url | https://www.mdpi.com/2079-6374/13/1/88 |
| work_keys_str_mv | AT sulaimanyalfaifi sensitiveandrapiddetectionofasparticacidwithcosub3subosub4subznonanorodsusingdifferentialpulsevoltammetry AT waheedabiodunadeosun sensitiveandrapiddetectionofasparticacidwithcosub3subosub4subznonanorodsusingdifferentialpulsevoltammetry AT abdullahmasiri sensitiveandrapiddetectionofasparticacidwithcosub3subosub4subznonanorodsusingdifferentialpulsevoltammetry AT mohammedmrahman sensitiveandrapiddetectionofasparticacidwithcosub3subosub4subznonanorodsusingdifferentialpulsevoltammetry |